Effects of a dairy product fortified with multiple micronutrients and omega-3 fatty acids on birth weight and gestation duration in pregnant Chilean women

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dc.contributor.authorMardones, Francisco
dc.contributor.authorUrrutia, Maria Teresa
dc.contributor.authorVillarroel, Luis
dc.contributor.authorRioseco, Alonso
dc.contributor.authorCastillo, Oscar
dc.contributor.authorRozowski, Jaime
dc.contributor.authorTapia, Jose Luis
dc.contributor.authorBastias, Gabriel
dc.contributor.authorBacallao, Jorge
dc.contributor.authorRojas, Ivan
dc.date.accessioned2024-01-10T12:05:08Z
dc.date.available2024-01-10T12:05:08Z
dc.date.issued2008
dc.description.abstractobjective: To test the hypothesis that maternal food fortification with omega-3 fatty acids and multiple micronutrients increases birth weight and gestation duration, as primary outcomes.
dc.description.abstractDesign: Non-blinded, randomised controlled study.
dc.description.abstractSetting: Pregnant women received powdered milk during their health check-ups at 19 antenatal clinics and delivered at two maternity hospitals in Santiago, Chile. Subject: Pregnant women were assigned to receive regular powdered milk (n = 477) or a milk product fortified with multiple micronutrients and omega-3 fatty acids (n = 495).
dc.description.abstractResults: Intention-to-treat analysis showed that mean birth weight was higher in the intervention group than in controls (65.4 g difference, 95% confidence interval (CI) 5-126 g; P = 0.03) and the incidence of very preterm birth (<34 weeks) was lower (0.4% vs. 2.1%; P = 0.03). On-treatment analysis showed a mean birth weight difference of 118 g (95% CI 47-190 g; P = 0.001) and a relative fall in both the proportion of birth weight <= 3000g (P = 0.015) and the incidence of preeclampsia (P = 0.015). Compliance with the experimental product was apparent from a haematological study of red-blood-cell folate at the end of pregnancy, which was performed in a sub-sample. in both types of analyses, positive differences were also present for mean gestation duration, birth length and head circumference. Nevertheless, the relatively small sample sizes allowed a statistical power of >0.80 just for mean birth weight and birth length in the on-treatment analysis; birth length in that analysis had a difference of 0.57cm (95% CI 0.19-0.96 cm; P = 0.003).
dc.description.abstractConclusions: The new intervention resulted in increased mean birth weight. Associations with gestation duration and most secondary outcomes need a larger sample size for confirmation.
dc.fechaingreso.objetodigital2024-04-25
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1017/S1368980007000110
dc.identifier.eissn1475-2727
dc.identifier.issn1368-9800
dc.identifier.pubmedidMEDLINE:17565762
dc.identifier.urihttps://doi.org/10.1017/S1368980007000110
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75952
dc.identifier.wosidWOS:000252676300006
dc.information.autorucMedicina;Bastías G;S/I;491
dc.information.autorucMedicina;Castillo O;S/I;1000391
dc.information.autorucMedicina;Mardones F;S/I;98805
dc.information.autorucMedicina;Rioseco A;S/I;61709
dc.information.autorucMedicina;Rozowski J;S/I;98948
dc.information.autorucMedicina;Tapia J;S/I;99000
dc.information.autorucEnfermería;Urrutia M;S/I;5100
dc.information.autorucMedicina;Villarroel L;S/I;77182
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final40
dc.pagina.inicio30
dc.publisherCAMBRIDGE UNIV PRESS
dc.revistaPUBLIC HEALTH NUTRITION
dc.rightsacceso restringido
dc.subjectmaternal nutrition
dc.subjectfood supplementation
dc.subjectmultiple micronutrients
dc.subjectomega-3 fatty acids
dc.subjectbirth weight
dc.subjectgestation duration
dc.subjectNUTRITIONAL-STATUS
dc.subjectDOUBLE-BLIND
dc.subjectFATTY-ACIDS
dc.subjectCOMMUNITY
dc.subjectSUPPLEMENTATION
dc.subjectTRIAL
dc.subjectINTERVENTIONS
dc.subjectCONSUMPTION
dc.subjectOUTCOMES
dc.subjectGROWTH
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of a dairy product fortified with multiple micronutrients and omega-3 fatty acids on birth weight and gestation duration in pregnant Chilean women
dc.typeartículo
dc.volumen11
sipa.codpersvinculados491
sipa.codpersvinculados1000391
sipa.codpersvinculados98805
sipa.codpersvinculados61709
sipa.codpersvinculados98948
sipa.codpersvinculados99000
sipa.codpersvinculados5100
sipa.codpersvinculados77182
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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