Functional Dysconnectivity in Ventral Striatocortical Systems in 22q11.2 Deletion Syndrome

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dc.catalogadorpau
dc.contributor.authorTepper, Angeles
dc.contributor.authorCuiza Vasquez Analia
dc.contributor.authorAlliende, Luz María
dc.contributor.authorMena, Carlos
dc.contributor.authorRamirez Mahaluf, Juan Pablo
dc.contributor.authorIruretagoyena, Barbara
dc.contributor.authorOrnstein, Claudia
dc.contributor.authorFritsch, Rosemarie
dc.contributor.authorNachar, Ruben
dc.contributor.authorGonzalez Valderrama, Alfonso
dc.contributor.authorUndurraga, Juan
dc.contributor.authorPablo Cruz, Juan
dc.contributor.authorTejos, Cristian
dc.contributor.authorFornito, Alex
dc.contributor.authorRepetto, Gabriela
dc.contributor.authorCrossley, Nicolas
dc.date.accessioned2024-06-10T14:41:12Z
dc.date.available2024-06-10T14:41:12Z
dc.date.issued2021
dc.description.abstract22q11.2 deletion syndrome (22q11.2DS) is a genetic neurodevelopmental disorder that represents one of the greatest known risk factors for psychosis. Previous studies in psychotic subjects without the deletion have identified a dopaminergic dysfunction in striatal regions, and dysconnectivity of striatocortical systems, as an important mechanism in the emergence of psychosis. Here, we used resting-state functional MRI to examine striatocortical functional connectivity in 22q11.2DS patients. We used a 2 x 2 factorial design including 125 subjects (55 healthy controls, 28 22q11.2DS patients without a history of psychosis, 10 22q11.2DS patients with a history of psychosis, and 32 subjects with a history of psychosis without the deletion), allowing us to identify network effects related to the deletion and to the presence of psychosis. In line with previous results from psychotic patients without 22q11.2DS, we found that there was a dorsal to ventral gradient of hypo- to hyperstriatocortical connectivity related to psychosis across both patient groups. The 22q11.2DS was additionally associated with abnormal functional connectivity in ventral striatocortical networks, with no significant differences identified in the dorsal system. Abnormalities in the ventral striatocortical system observed in these individuals with high genetic risk to psychosis may thus reflect a marker of illness risk.
dc.description.funderAgencia Nacional de Investigacion y Desarrollo from Chile (ANID)
dc.description.funderFONDECYT regular
dc.description.funderMillennium Nucleus for Cardiovascular Disease
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1093/schbul/sbab139
dc.identifier.eissn1745-1701
dc.identifier.issn0586-7614
dc.identifier.pubmedidMEDLINE:34931688
dc.identifier.urihttps://doi.org/10.1093/schbul/sbab139
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86659
dc.identifier.wosidWOS:000764682700001
dc.information.autorucEscuela de Medicina; Tepper, Angeles; S/I; 1070622
dc.information.autorucEscuela de Enfermería; Cuiza Vasquez Analia; S/I; 502
dc.information.autorucEscuela de Medicina; Iruretagoyena, Barbara; S/I; 164907
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherOXFORD UNIV PRESS
dc.revistaSCHIZOPHRENIA BULLETIN
dc.rightsacceso restringido
dc.subjectFunctional connectivity
dc.subjectDopaminergic systems
dc.subjectStriatal connectivity
dc.subjectGenetic risk to psychosis
dc.subjectANTERIOR CINGULATE CORTEX
dc.subjectDOPAMINE HYPOTHESIS
dc.subjectSCHIZOPHRENIA
dc.subjectRISK
dc.subjectCONNECTIVITY
dc.subjectRELIABILITY
dc.subjectPSYCHOSIS
dc.subjectASSOCIATION
dc.subjectVALIDITY
dc.subjectADULTS
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleFunctional Dysconnectivity in Ventral Striatocortical Systems in 22q11.2 Deletion Syndrome
dc.typeartículo
sipa.codpersvinculados1070622
sipa.codpersvinculados502
sipa.codpersvinculados164907
sipa.trazabilidadWOS;18-03-2022
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