Myocardial T1, T2, T2*, and fat fraction quantification via low-rank motion-corrected cardiac MR fingerprinting

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dc.contributor.authorda Cruz, Gastao Jose Lima
dc.contributor.authorVelasco, Carlos
dc.contributor.authorLavin, Begona
dc.contributor.authorJaubert, Olivier
dc.contributor.authorMichael Botnar, Rene
dc.contributor.authorPrieto, Claudia
dc.date.accessioned2024-01-10T13:45:04Z
dc.date.available2024-01-10T13:45:04Z
dc.date.issued2022
dc.description.abstractPurpose Develop a novel 2D cardiac MR fingerprinting (MRF) approach to enable simultaneous T1, T2, T2*, and fat fraction (FF) myocardial tissue characterization in a single breath-hold scan. Methods Simultaneous, co-registered, multi-parametric mapping of T1, T2, and FF has been recently achieved with cardiac MRF. Here, we further incorporate T2* quantification within this approach, enabling simultaneous T1, T2, T2*, and FF myocardial tissue characterization in a single breath-hold scan. T2* quantification is achieved with an eight-echo readout that requires a long cardiac acquisition window. A novel low-rank motion-corrected (LRMC) reconstruction is exploited to correct for cardiac motion within the long acquisition window. The proposed T1/T2/T2*/FF cardiac MRF was evaluated in phantom and in 10 healthy subjects in comparison to conventional mapping techniques. Results The proposed approach achieved high quality parametric mapping of T1, T2, T2*, and FF with corresponding normalized RMS error (RMSE) T1 = 5.9%, T2 = 9.6% (T2 values <100 ms), T2* = 3.3% (T2* values <100 ms), and FF = 0.8% observed in phantom scans. In vivo, the proposed approach produced higher left-ventricular myocardial T1 values than MOLLI (1148 vs 1056 ms), lower T2 values than T2-GraSE (42.8 vs 50.6 ms), lower T2* values than eight-echo gradient echo (GRE) (35.0 vs 39.4 ms), and higher FF values than six-echo GRE (0.8 vs 0.3 %) reference techniques. The proposed approach achieved considerable reduction in motion artifacts compared to cardiac MRF without motion correction, improved spatial uniformity, and statistically higher apparent precision relative to conventional mapping for all parameters. Conclusion The proposed cardiac MRF approach enables simultaneous, co-registered mapping of T1, T2, T2*, and FF in a single breath-hold for comprehensive myocardial tissue characterization, achieving higher apparent precision than conventional methods.
dc.description.funderEPSRC
dc.description.funderWellcome EPSRC Centre for Medical Engineering
dc.description.funderFONDECYT
dc.description.funderANID - Millennium Science Initiative Program
dc.description.funderDepartment of Health through the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award
dc.description.funderKing's College London
dc.description.funderKing's College Hospital NHS Foundation Trust
dc.description.funderNIHR MedTech Co-operative for Cardiovascular Disease at Guy's and St Thomas' NHS Foundation Trust
dc.description.funderEPSRC Centre for Doctorial Training in Medical Imaging
dc.description.funderPhilips Healthcare
dc.fechaingreso.objetodigital2024-04-09
dc.format.extent18 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/mrm.29171
dc.identifier.eissn1522-2594
dc.identifier.issn0740-3194
dc.identifier.pubmedidMEDLINE:35081260
dc.identifier.urihttps://doi.org/10.1002/mrm.29171
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78978
dc.identifier.wosidWOS:000746914900001
dc.information.autorucFacultad de Ingeniería; Prieto Vasquez, Claudia Del Carmen; S/I; 14195
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherWILEY
dc.revistaMAGNETIC RESONANCE IN MEDICINE
dc.rightsacceso abierto
dc.subjectcardiac MR
dc.subjectfat fraction
dc.subjectlow rank
dc.subjectmotion correction
dc.subjectMR fingerprinting
dc.subjectT1 mapping
dc.subjectT2 mapping
dc.subjectT2*mapping
dc.subjectMAGNETIC-RESONANCE
dc.subjectINVERSION-RECOVERY
dc.subjectRECONSTRUCTION
dc.subjectT-1
dc.subjectSEPARATION
dc.subjectSTATEMENT
dc.subjectDIAGNOSIS
dc.subjectHEART
dc.subjectSENSE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMyocardial T1, T2, T2*, and fat fraction quantification via low-rank motion-corrected cardiac MR fingerprinting
dc.typeartículo
sipa.codpersvinculados14195
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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