Pharmacogenetics in Psychiatry: Perceived Value and Opinions in a Chilean Sample of Practitioners

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dc.catalogadorpau
dc.contributor.authorUndurraga, Juan
dc.contributor.authorBórquez Infante, Ignacio
dc.contributor.authorCrossley, Nicolás
dc.contributor.authorPrieto, Miguel L.
dc.contributor.authorRepetto, Gabriela M.
dc.date.accessioned2024-06-10T16:40:42Z
dc.date.available2024-06-10T16:40:42Z
dc.date.issued2021
dc.description.abstractUse of pharmacogenetics (PGx) testing to guide clinical decisions is growing in developed countries. Published guidelines for gene-drug pair analysis are available for prescriptions in psychiatry, but information on their utilization, barriers, and health outcomes in Latin America is limited. As a result, this work aimed at exploring current use, opinions, and perceived obstacles on PGx testing among psychiatrists in Chile, via an online, anonymous survey. Among 123 respondents (5.9% of registered psychiatrists in the country), 16.3% reported ever requesting a PGx test. The vast majority (95%) of tests were ordered by clinicians practicing in the Metropolitan Region of Santiago. Having more than 20 years in practice was positively associated with prior use of PGx (p 0.02, OR 3.74 (1.19-11.80)), while working in the public health system was negatively associated (OR 0.30 (0.10-0.83)). Perceived barriers to local implementation included insufficient evidence of clinical utility, limited clinicians' knowledge on PGx and on test availability, and health systems' issues, such as costs and reimbursement. Despite the recognition of these barriers, 80% of respondents asserted that it is likely that they will incorporate PGx tests in their practice in the next five years. Given these results, we propose next steps to facilitate implementation such as further research in health outcomes and clinical utility of known and novel clinically actionable variants, growth in local sequencing capabilities, education of clinicians, incorporation of clinical decision support tools, and economic evaluations, all in local context.
dc.fechaingreso.objetodigital2024-06-10
dc.fuente.origenConveris
dc.identifier.doi10.3389/fphar.2021.657985
dc.identifier.issn1663-9812
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85104958889
dc.identifier.urihttps://doi.org/10.3389/fphar.2021.657985
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86667
dc.identifier.wosidWOS:000645277500001
dc.information.autorucInstituto de Sociología; Bórquez Infante, Ignacio; S/I; 221670
dc.information.autorucEscuela de Medicina; Crossley, Nicolás; 0000-0002-3060-656X; 11224
dc.nota.accesocontenido completo
dc.revistaFrontiers in Pharmacology
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePharmacogenetics in Psychiatry: Perceived Value and Opinions in a Chilean Sample of Practitioners
dc.typeartículo
dc.volumen12
sipa.codpersvinculados221670
sipa.codpersvinculados11224
sipa.trazabilidadConveris;20-07-2021
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