Intrahepatic fatty acids composition as a biomarker of NAFLD progression from steatosis to NASH by using 1H-MRS

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dc.catalogadorpva
dc.contributor.authorXavier, Aline Carvalho da Silva
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorGaínza Kunstmann, Constanza Mikela
dc.contributor.authorCabrera García, Daniel Alejandro
dc.contributor.authorArrese, Marco
dc.contributor.authorUribe Arancibia, Sergio A.
dc.contributor.authorSing-Long C., Carlos A.
dc.contributor.authorAndía Kohnenkampf, Marcelo Edgardo
dc.date.accessioned2023-05-19T20:50:00Z
dc.date.available2023-05-19T20:50:00Z
dc.date.issued2019
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world and it is becoming one of the most frequent cause of liver transplantation. Unfortunately, the only available method that can reliably determine the stage of this disease is liver biopsy, however, it is invasive and risky for patients. The purpose of this study is to investigate changes in the intracellular composition of the liver fatty acids during the progression of the NAFLD in a mouse model fed with Western diet, with the aim of identify non-invasive biomarkers of NAFLD progression based in H-1-MRS. Our results showed that the intracellular liver fatty acid composition changes as NAFLD progresses from simple steatosis to steatohepatitis (NASH). Using principal component analysis with a clustering method, it was possible to identify the three most relevant clinical groups: normal, steatosis and NASH by using H-1-MRS. These results showed a good agreement with the results obtained by GC-MS and histology. Our results suggest that it would be possible to detect the progression of simple steatosis to NASH using H-1-MRS, that has the potential to be used routinely in clinical application for screening high-risk patients.
dc.fechaingreso.objetodigital2023-08-25
dc.fuente.origenORCID
dc.identifier.doi10.1039/C9RA08914D
dc.identifier.issn2046-2069
dc.identifier.urihttps://doi.org/10.1039/C9RA08914D
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/70124
dc.identifier.wosidWOS:000516545700017
dc.information.autorucEscuela de Ingeniería; Xavier, Aline Carvalho da Silva; 0000-0001-6793-341X; 1030565
dc.information.autorucEscuela de Química; Zacconi, Flavia C. M.; 0000-0002-3676-0453; 1011127
dc.information.autorucEscuela de Ingeniería; Xavier, Aline Carvalho da Silva; 0000-0001-6793-341X; 1030565
dc.information.autorucEscuela de Química; Zacconi, Flavia C. M.; 0000-0002-3676-0453; 1011127
dc.information.autorucEscuela de Ingeniería; Gaínza Kunstmann, Constanza Mikela; 0000-0002-2660-318X; 232807
dc.information.autorucEscuela de Medicina; Cabrera García, Daniel Alejandro; 0000-0002-5891-0459; 126029
dc.information.autorucEscuela de Medicina; Arrese, Marco; 0000-0002-0499-4191; 76095
dc.information.autorucEscuela de Medicina; Uribe Arancibia, Sergio A.; S/I; 16572
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Sing-Long C., Carlos A.; 0000-0002-2533-2509; 126170
dc.information.autorucEscuela de Medicina; Andía Kohnenkampf, Marcelo Edgardo; 0000-0002-1251-5832; 90691
dc.issue.numero72
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final42139
dc.pagina.inicio42132
dc.revistaRSC Advanceses_ES
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIntrahepatic fatty acids composition as a biomarker of NAFLD progression from steatosis to NASH by using 1H-MRSes_ES
dc.typeartículo
dc.volumen9
sipa.indexISI
sipa.indexScopus
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