Abnormalities of lipid metabolism, gallstone disease and gallbladder function

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dc.catalogadorpau
dc.contributor.authorZanlungo Matsuhiro, Silvana
dc.contributor.authorMiquel P., Juan Francisco
dc.contributor.authorRigotti Rivera, Attilio
dc.contributor.authorNervi, Flavio
dc.date.accessioned2024-08-12T16:30:37Z
dc.date.available2024-08-12T16:30:37Z
dc.date.issued2011
dc.description.abstractGallstone disease is highly prevalent with a complex and multifactorial pathogenesis. Gallstones are closely related to the metabolic syndrome associated disease conditions in which abnormal regulation of lipid metabolism secondary to insulin resistance plays a major pathogenic role. Insulin resistance increases biliary cholesterol secretion and affects gallbladder (GB) motility. Regulation of lipid metabolism and energy homeostasis is complex and the GB has been considered to have a minor regulatory role in both the intestinal absorption of lipids and metabolic homeostasis of the whole body. In fact, ablation of the GB does not affect nutrient absorption or the ability to lead a normal life. GB function regulates the cycling of bile salts through the enterohepatic circulation. Bile salts have important signaling effects that can affect whole body metabolic homeostasis. The GB and intestinal mucosa are rich in the hormone FGF15/19 and the receptor TGR5, which participate in metabolic regulation. Recent evidence supports the hypothesis that cholecystectomy may not be innocuous and that the GB has a significant role in the regulation of hepatic triglyceride metabolism. This article provides information regarding recent advances in the understanding of the interaction between regulation of lipid metabolism, insulin resistance, gallstone disease and GB function.
dc.description.funderFONDECYT
dc.fuente.origenHistorial Académico
dc.identifier.citationZanlungo S , Rigotti A , Miquel J, Nervi F. Abnormalities of lipid metabolism, gallstone disease and gallbladder function . Clinical Lipidology. 2011;6(3):315-325.
dc.identifier.doi10.2217/CLP.11.22
dc.identifier.issn1758-4299
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87419
dc.identifier.wosidWOS:000292355700011
dc.information.autorucEscuela de Medicina; Zanlungo Matsuhiro, Silvana; 0000-0001-8383-9829; 72650
dc.information.autorucEscuela de Medicina; Miquel P., Juan Francisco; 0000-0002-0526-4377; 72216
dc.information.autorucEscuela de Medicina; Rigotti Rivera, Attilio; 0000-0002-0495-3525; 68489
dc.information.autorucEscuela de Medicina; Nervi, Flavio; 0000-0002-6642-7985; 99156
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final325
dc.pagina.inicio315
dc.revistaCLINICAL LIPIDOLOGY
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleAbnormalities of lipid metabolism, gallstone disease and gallbladder function
dc.typeartículo
dc.volumen6
sipa.codpersvinculados72650
sipa.codpersvinculados72216
sipa.codpersvinculados68489
sipa.codpersvinculados99156
sipa.trazabilidadHistorial Académico;09-07-2021
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