La vía de señalización Rho/Rho-cinasa en la enfermedad y el remodelado cardiovascular

Simple item page
dc.catalogadorvzp
dc.contributor.authorJalil Milad, Jorge Emilio
dc.contributor.authorLavandero, Sergio
dc.contributor.authorChiong, Mario
dc.contributor.authorOcaranza Jeraldino, María Paz
dc.date.accessioned2024-06-07T13:53:38Z
dc.date.available2024-06-07T13:53:38Z
dc.date.issued2005
dc.description.abstractThe small guanosine triphosphatase Rho and its target, Rho kinase, play important roles in both blood pressure regulation and vascular smooth muscle contraction. Rho is activated by agonists of receptors coupled to cell membrane G protein, such as angiotensin II and phenylephrine. Once Rho is activated, it translocates to the cell membrane where it, in turn, activates Rho kinase. Activated Rho kinase phosphorylates myosin light chain phosphatase, which is then inhibited. This sequence stimulates vascular smooth muscle contraction, stress fiber formation, and cell migration. In this way, Rho and Rho kinase activation have important effects on several cardiovascular diseases. Currently available substances that specifically inhibit this signaling pathway could offer clinical benefits in several cardiovascular, as well as non-cardiovascular, diseases, such as arterial hypertension, pulmonary hypertension, cerebral or coronary spasm, post-angioplasty restenosis, and erectile dysfunction.
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1157/13078132
dc.identifier.issn0300-8932
dc.identifier.pubmedidMEDLINE:16053829
dc.identifier.urihttps://doi.org/10.1157/13078132
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86623
dc.identifier.wosidWOS:000231652800010
dc.information.autorucEscuela de Medicina; Jalil Milad, Jorge Emilio; 0000-0001-6877-2072; 99946
dc.information.autorucEscuela de Medicina; Ocaranza Jeraldino, María Paz; 0000-0002-4915-6378; 1001254
dc.issue.numero8
dc.language.isoes
dc.nota.accesocontenido parcial
dc.pagina.final961
dc.pagina.inicio951
dc.publisherEDICIONES DOYMA S/L
dc.revistaRevista Española de Cardiología
dc.rightsacceso restringido
dc.subjectRho
dc.subjectRho kinase
dc.subjectSmall G proteins
dc.subjectArterial hypertension
dc.subjectCardiovascular remodeling
dc.subjectSmooth-muscle-cells
dc.subjectInduced hypertrophic responses
dc.subjectHuman endothelial cells
dc.subjectRho-Family Gtpases
dc.subjectCadiac myocytes
dc.subjectGene-expression
dc.subjectProtein-Kinase
dc.subjectNitric-Oxide
dc.subjectNadph Oxidase
dc.subjectAngiotesin
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.titleLa vía de señalización Rho/Rho-cinasa en la enfermedad y el remodelado cardiovascular
dc.title.alternativeRho/Rho Kinase Signal Transduction Pathway in Cardiovascular Disease and Cardiovascular Remodeling
dc.typeartículo de revisión
dc.volumen58
sipa.codpersvinculados99946
sipa.codpersvinculados1001254
sipa.trazabilidadWOS;05-06-2021
Files
Collections
Artículos de revistas