FOLLICLE-STIMULATING HORMONE-GRANULOSA CELL AXIS INVOLVEMENT IN THE ANTIFOLLICULOTROPHIC EFFECT OF LOW-DOSE MIFEPRISTONE (RU486)

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dc.contributor.authorCROXATTO, HB
dc.contributor.authorSALVATIERRA, AM
dc.contributor.authorFUENTEALBA, B
dc.contributor.authorLEIVA, L
dc.date.accessioned2024-01-10T12:05:32Z
dc.date.available2024-01-10T12:05:32Z
dc.date.issued1995
dc.description.abstractThis study was designed to assess the involvement of follicle stimulating hormone (FSH)-granulosa and luteinizing hormone (LH)-theca axes in the antifolliculotrophic effect of mifepristone. Plasma gonadotrophins, including plasma LH bioactivity and pulsatility, oestradiol, testosterone and inhibin concentrations, and follicular growth were monitored in volunteer women treated with placebo or mifepristone in two consecutive cycles. Mifepristone was given either as a single dose of 5 mg (n = 7) when the leading follicle had reached a diameter between 12 and 14 mm, or as a multiple dose of 5 mg/day for 3 days, beginning when the leading follicle had reached a diameter between 14 and 16 mm (n = 5) or between 6 and 11 mm (n = 5), Following the single dose of mifepristone, follicular growth and the accompanying increase in plasma oestradiol were arrested at 12 and 36 h respectively without changes in gonadotrophin or testosterone serum concentrations. The 3 day regimen arrested follicular growth and oestradiol rise and decreased plasma inhibin concentrations when follicles were larger than 12 mm at the onset of treatment. These results indicate that the antifolliculotrophic action of mifepristone is associated with a selective compromise of the FSH-granulosa axis of dominant follicles that have passed a critical stage of growth.
dc.fechaingreso.objetodigital2024-04-29
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1093/oxfordjournals.humrep.a136221
dc.identifier.issn0268-1161
dc.identifier.pubmedidMEDLINE:8567827
dc.identifier.urihttps://doi.org/10.1093/oxfordjournals.humrep.a136221
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76026
dc.identifier.wosidWOS:A1995RU03700012
dc.information.autorucCiencias Biológicas;Croxatto H;S/I;98164
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1991
dc.pagina.inicio1987
dc.publisherOXFORD UNIV PRESS UNITED KINGDOM
dc.revistaHUMAN REPRODUCTION
dc.rightsacceso restringido
dc.subjectFOLLICULAR GROWTH
dc.subjectGONADOTROPINS
dc.subjectINHIBIN
dc.subjectMIFEPRISTONE
dc.subjectMENSTRUAL-CYCLE
dc.subjectANTIPROGESTERONE RU-486
dc.subjectNORMAL WOMEN
dc.subjectPHASE
dc.subjectPROGESTERONE
dc.subjectOVULATION
dc.subjectSECRETION
dc.subjectINHIBIN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFOLLICLE-STIMULATING HORMONE-GRANULOSA CELL AXIS INVOLVEMENT IN THE ANTIFOLLICULOTROPHIC EFFECT OF LOW-DOSE MIFEPRISTONE (RU486)
dc.typeartículo
dc.volumen10
sipa.codpersvinculados98164
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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