Prenatal to Early Postnatal Nicotine Exposure Impairs Central Chemoreception and Modifies Breathing Pattern in Mouse Neonates: A Probable Link to Sudden Infant Death Syndrome

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dc.contributor.authorEugenin, Jaime
dc.contributor.authorOtarola, Marcelo
dc.contributor.authorBravo, Eduardo
dc.contributor.authorCoddou, Claudio
dc.contributor.authorCerpa, Veronica
dc.contributor.authorReyes Parada, Miguel
dc.contributor.authorLlona, Isabel
dc.contributor.authorvon Bernhardi, Rommy
dc.date.accessioned2024-01-10T12:07:40Z
dc.date.available2024-01-10T12:07:40Z
dc.date.issued2008
dc.description.abstractNicotine is a neuroteratogen and is the likely link between maternal cigarette smoking during pregnancy and sudden infant death syndrome (SIDS). Osmotic minipumps were implanted in 5-7 d CF1 pregnant mice to deliver nicotine bitartrate (60 mg Kg(-1) day(-1)) or saline (control) solutions for up to 28 d. Prenatal to early postnatal nicotine exposure did not modify the number of newborns per litter or their postnatal growth; however, nicotine-exposed neonates hypoventilated and had reduced responses to hypercarbia (inhalation of air enriched with 10% CO2 for 20 min) and hypoxia (inhalation of 100% N-2 for 20 s) at postnatal days 0-3 (P0-P3). In contrast, at postnatal day 8, nicotine-exposed neonates were indistinguishable from controls. Isolated brainstem-spinal cord preparations obtained from P0 to P3 nicotine-exposed neonates showed fictive respiration with respiratory cycles longer and more irregular than those of controls, as indicated by high short- and long-term variability in Poincare plots. In addition, their responses to acidification were reduced, indicating compromise of central chemoreception. Furthermore, the cholinergic contribution to central chemosensory responses switched from muscarinic receptor to nicotinic receptor-based mechanisms. No significant astrogliosis was detectable in the ventral respiratory group of neurons with glial fibrillary acidic protein immunohistochemistry. These results indicate that nicotine exposure affects the respiratory rhythm pattern generator and causes a decline in central chemoreception during early postnatal life. Consequently, breathing would become highly vulnerable, failing to respond to chemosensory demands. Such impairment could be related to the ventilatory abnormalities observed in SIDS.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Technologico
dc.description.funderDepartamento de Investigaciones Cientificas y Technologicas - Universidad de Santiago de Chile (USACH)
dc.description.funderVicerrectoria de Investigacion y Desarrollo
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1523/JNEUROSCI.4441-08.2008
dc.identifier.issn0270-6474
dc.identifier.pubmedidMEDLINE:19091979
dc.identifier.urihttps://doi.org/10.1523/JNEUROSCI.4441-08.2008
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76310
dc.identifier.wosidWOS:000261780100019
dc.information.autorucMedicina;Von Bernhardi R;S/I;62523
dc.issue.numero51
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final13917
dc.pagina.inicio13907
dc.publisherSOC NEUROSCIENCE
dc.revistaJOURNAL OF NEUROSCIENCE
dc.rightsregistro bibliográfico
dc.subjectnicotine
dc.subjectcentral chemoreception
dc.subjectrespiratory rhythm generator
dc.subjectsudden infant death syndrome
dc.subjecthypercarbia
dc.subjecthypoxia
dc.subjectacetylcholine
dc.subjectCIGARETTE-SMOKE EXPOSURE
dc.subjectBRAIN-STEM GLIOSIS
dc.subjectCHOLINERGIC-RECEPTORS
dc.subjectVENTILATORY RESPONSES
dc.subjectGENE-EXPRESSION
dc.subjectFETAL NICOTINE
dc.subjectNEWBORN RAT
dc.subjectSLEEP-APNEA
dc.subjectRISK-FACTOR
dc.subjectIN-VITRO
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePrenatal to Early Postnatal Nicotine Exposure Impairs Central Chemoreception and Modifies Breathing Pattern in Mouse Neonates: A Probable Link to Sudden Infant Death Syndrome
dc.typeartículo
dc.volumen28
sipa.codpersvinculados62523
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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