Replenishment of type VII collagen and re-epithelialization of chronically ulcerated skin after intradermal administration of allogeneic mesenchymal stromal cells in two patients with recessive dystrophic epidermolysis bullosa

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dc.contributor.authorConget, Paulette
dc.contributor.authorRodriguez, Fernando
dc.contributor.authorKramer, Susanne
dc.contributor.authorAllers, Carolina
dc.contributor.authorSimon, Valeska
dc.contributor.authorPalisson, Francis
dc.contributor.authorGonzalez, Sergio
dc.contributor.authorYubero, Maria J.
dc.date.accessioned2024-01-10T12:42:06Z
dc.date.available2024-01-10T12:42:06Z
dc.date.issued2010
dc.description.abstractIn animal models it has been shown that mesenchymal stromal cells (MSC) contribute to skin regeneration and accelerate wound healing. We evaluated whether allogeneic MSC administration resulted in an improvement in the skin of two patients with recessive dystrophic epidermolysis bullosa (RDEB; OMIM 226600). Patients had absent type VII collagen immunohistofluorescence and since birth had suffered severe blistering and wounds that heal with scarring. Vehicle or 0.5x10<SU6</SU MSC were infused intradermally in intact and chronic ulcerated sites. One week after intervention, in MSC-treated skin type VII collagen was detected along the basement membrane zone and the dermal-epidermal junction was continuous. Re-epithelialization of chronic ulcerated skin was observed only near MSC administration sites. In both patients the observed clinical benefit lasted for 4 months. Thus intradermal administration of allogeneic MSC associates with type VII collagen replenishment at the dermal-epidermal junction, prevents blistering and improves wound healing in unconditioned patients with RDEB.
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent3 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/14653241003587637
dc.identifier.issn1465-3249
dc.identifier.pubmedidMEDLINE:20230217
dc.identifier.urihttps://doi.org/10.3109/14653241003587637
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77481
dc.identifier.wosidWOS:000276362100018
dc.information.autorucMedicina;González S;S/I;99856
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final431
dc.pagina.inicio429
dc.publisherINFORMA HEALTHCARE
dc.revistaCYTOTHERAPY
dc.rightsacceso restringido
dc.subjectchronic wound healing
dc.subjectdystrophic epidermolysis bullosa
dc.subjectmesenchymal stromal cell
dc.subjectSTEM-CELLS
dc.subjectINJECTION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleReplenishment of type VII collagen and re-epithelialization of chronically ulcerated skin after intradermal administration of allogeneic mesenchymal stromal cells in two patients with recessive dystrophic epidermolysis bullosa
dc.typeartículo
dc.volumen12
sipa.codpersvinculados99856
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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