Imaging the extracellular matrix in prevalent cardiovascular diseases

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dc.catalogadorjwg
dc.contributor.authorChaher, Nadia
dc.contributor.authorHajhosseiny, Reza
dc.contributor.authorPhinikaridou, Alkystis
dc.contributor.authorBotnar, René Michael
dc.date.accessioned2024-05-07T20:27:09Z
dc.date.available2024-05-07T20:27:09Z
dc.date.issued2020
dc.description.abstractThe extracellular matrix (ECM) is a highly complex macromolecular network present in all tissues and organs. The ECM is continuously remodelling under an orchestrated process facilitated by many matrix-degrading and matrix-synthesising enzymes in both health and disease. Disturbance of this balance can be the result of or can lead to various diseases. In cardiovascular diseases (CVDs), changes to the ECM are evident in conditions including: atherosclerosis, myocardial infarction (MI), venous thromboembolism (VTE) and abdominal aortic aneurysm (AAA). ECM proteins and ECM regulating enzymes are differently expressed in various CVDs. Most importantly, the altered deposition, macromolecule arrangement and activity of the ECM makes it an attractive marker of disease onset, pathogenesis and progression. Many medical imaging modalities allow disease assessment by exploiting native image contrast, by using non-targeted or by using protein or cell specific (targeted) imaging probes. However, the ability to directly visualise and quantify changes in specific ECM proteins enhances our understanding of the biological role of these proteins, enables monitoring of disease progression and response to treatment and may improve patient diagnosis and allocation of personalised therapies. This review focuses on the biochemistry of the major extracellular matrix proteins and advancements in the development of ECM-targeted probes for molecular imaging of CVD, particularly for applications of molecular magnetic resonance imaging (MRI) and position emission tomography (PET) imaging.
dc.description.funderCardiovascular Health Technology Cooperative
dc.description.funderHTC
dc.description.funderWellcome EPSRC Centre for Medical Engineering
dc.description.funderKing's College Hospital NHS Foundation Trust
dc.description.funderBiomedical Research Centre
dc.description.funderEPSRC
dc.description.funderNational Institute for Health Research
dc.description.funderBHF
dc.description.funderDepartment of Health
dc.description.funderKing's College London
dc.fuente.origenScopus
dc.identifier.doi10.3390/app10114001
dc.identifier.eissn20763417
dc.identifier.issn20763417
dc.identifier.scopusidSCOPUS_ID:85086945586
dc.identifier.urihttps://res.mdpi.com/d_attachment/applsci/applsci-10-04001/article_deploy/applsci-10-04001-v2.pdf
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/85490
dc.identifier.wosidWOS:000543385900338
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Botnar Rene Michael; 0000-0002-9447-4367; 1015313
dc.issue.numero4001
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherMDPI AG
dc.revistaApplied Sciences (Switzerland)
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImaging the extracellular matrix in prevalent cardiovascular diseases
dc.typeartículo de revisión
dc.volumen10
sipa.codpersvinculados1015313
sipa.trazabilidadORCID;2024-01-15
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