Maternal HLA Panel-Reactive Antibodies in Early Gestation Positively Correlate with Chronic Chorioamnionitis: Evidence in Support of the Chronic Nature of Maternal Anti-fetal Rejection

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dc.contributor.authorLee, JoonHo
dc.contributor.authorRomero, Roberto
dc.contributor.authorXu, Yi
dc.contributor.authorKim, Jung Sun
dc.contributor.authorPark, Ji Young
dc.contributor.authorPedro Kusanovic, Juan
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorHassan, Sonia S.
dc.contributor.authorKim, Chong Jai
dc.date.accessioned2024-01-10T12:06:29Z
dc.date.available2024-01-10T12:06:29Z
dc.date.issued2011
dc.description.abstractProblem
dc.description.abstractMaternal tolerance of the fetus is essential for viviparity, yet anti-fetal rejection occurs in several pregnancy complications. Chronic chorioamnionitis is a feature of anti-fetal cellular rejection. There is a robust association between chronic chorioamnionitis and maternal seropositivity for antihuman leukocyte antigen (HLA) panel-reactive antibodies (PRA) at the time of delivery. This longitudinal study was performed to assess maternal HLA PRA status in early gestation and the temporal evolution of maternal HLA PRA in the context of chronic chorioamnionitis and, thereby, to determine whether HLA PRA during the course of pregnancy is useful for the detection of anti-fetal rejection.
dc.description.abstractMethod of study
dc.description.abstractMaternal sera obtained before 16 weeks of gestation and at delivery were analyzed for HLA PRA in cases with (N = 100) and without (N = 150) chronic chorioamnionitis.
dc.description.abstractResults
dc.description.abstractIgG (but not IgM) HLA class I and II PRA positivity at delivery was higher in cases with chronic chorioamnionitis than in those without chronic chorioamnionitis. IgG HLA class I PRA positivity before 16 weeks of gestation was higher in cases with chronic chorioamnionitis than in those without (30.3 versus 13.3%; P = 0.001). Positive conversion (negative HLA PRA before 16 weeks of gestation but positive at delivery) of IgG HLA class I and II PRA was significantly associated with chronic chorioamnionitis. Fetal HLA class I antigen-specific antibodies were confirmed in 12 of 16 mothers tested who were sensitized to HLA class I antigens before 16 weeks of gestation.
dc.description.abstractConclusion
dc.description.abstractPositive maternal HLA PRA before 16 weeks of gestation and the temporal evolution of maternal HLA PRA are associated with the presence of chronic chorioamnionitis at the time of delivery. Maternal IgG HLA PRA has the potential to be a monitoring tool of anti-fetal rejection. Furthermore, the findings herein indicate that subsets of fetuses are exposed to alloimmune HLA antibodies for months, especially in cases with chronic chorioamnionitis.
dc.description.funderPerinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U. S. Department of Health and Human Services
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent17 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1600-0897.2011.01066.x
dc.identifier.eissn1600-0897
dc.identifier.issn1046-7408
dc.identifier.pubmedidMEDLINE:21951517
dc.identifier.urihttps://doi.org/10.1111/j.1600-0897.2011.01066.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76167
dc.identifier.wosidWOS:000296896300009
dc.information.autorucMedicina;Kusanovic J;S/I;1008900
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final526
dc.pagina.inicio510
dc.publisherWILEY
dc.revistaAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
dc.rightsacceso restringido
dc.subjectHuman leukocyte antigen
dc.subjectpanel-reactive antibody
dc.subjectpregnancy
dc.subjectpreterm birth
dc.subjectNEONATAL ALLOIMMUNE THROMBOCYTOPENIA
dc.subjectREGULATORY T-CELLS
dc.subjectIMMUNOGLOBULIN-G ANTIBODIES
dc.subjectINFLAMMATORY RESPONSE
dc.subjectUNKNOWN ETIOLOGY
dc.subjectALLOGRAFT PATHOLOGY
dc.subjectRECURRENT ABORTION
dc.subjectIMMUNE TOLERANCE
dc.subjectPRETERM BIRTH
dc.subjectFETAL
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleMaternal HLA Panel-Reactive Antibodies in Early Gestation Positively Correlate with Chronic Chorioamnionitis: Evidence in Support of the Chronic Nature of Maternal Anti-fetal Rejection
dc.typeartículo
dc.volumen66
sipa.codpersvinculados1008900
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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