Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test

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dc.catalogadorgrr
dc.contributor.authorFernandez Verdejo, Rodrigo Esteban
dc.contributor.authorMalo Vintimilla, Maria Lorena
dc.contributor.authorGutierrez Pino, Juan
dc.contributor.authorLopez Fuenzalida, Antonio Eduardo
dc.contributor.authorOlmos, Pablo
dc.contributor.authorIrarrazaval Mena, Pablo
dc.contributor.authorGalgani Fuentes, Jose Eduardo
dc.date.accessioned2024-05-28T15:02:20Z
dc.date.available2024-05-28T15:02:20Z
dc.date.issued2021
dc.description.abstractBackground: Low metabolic flexibility (MetF) may be an underlying factor for metabolic health impairment. Individuals with low MetF are thus expected to have worse metabolic health than subjects with high MetF. Therefore, we aimed to compare metabolic health in individuals with contrasting MetF to an oral glucose tolerance test (OGTT).Methods: In individuals with excess body weight, we measured MetF as the change in respiratory quotient (RQ) from fasting to 1 h after ingestion of a 75-g glucose load (i.e., OGTT). Individuals were then grouped into low and high MetF (Low-MetF n = 12; High-MetF n = 13). The groups had similar body mass index, body fat, sex, age, and maximum oxygen uptake. Metabolic health markers (clinical markers, insulin sensitivity/resistance, abdominal fat, and intrahepatic fat) were compared between groups.Results: Fasting glucose, triglycerides (TG), and high-density lipoprotein (HDL) were similar between groups. So were insulin sensitivity/resistance, visceral, and intrahepatic fat. Nevertheless, High-MetF individuals had higher diastolic blood pressure, a larger drop in TG concentration during the OGTT, and a borderline significant (P = 0.05) higher Subcutaneous Adipose Tissue (SAT). Further, compared to Low-MetF, High-MetF individuals had an about 2-fold steeper slope for the relationship between SAT and fat mass index.Conclusion: Individuals with contrasting MetF to an OGTT had similar metabolic health. Yet High-MetF appears related to enhanced circulating TG clearance and enlarged subcutaneous fat.
dc.description.funderANID/CONICYT FONDECYT Iniciacion
dc.description.funderANID/CONICYT FONDECYT
dc.fechaingreso.objetodigital2024-05-28
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3389/fnut.2021.745907
dc.identifier.issn2296-861X
dc.identifier.pubmedidMEDLINE:34869522
dc.identifier.urihttps://doi.org/10.3389/fnut.2021.745907
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/85837
dc.identifier.wosidWOS:000726110100001
dc.information.autorucDepartamento de Ciencias de la Salud; Fernandez Verdejo, Rodrigo Esteban; 0000-0002-5948-2281; 1071485
dc.information.autorucEscuela de Medicina; Malo Vintimilla, Maria Lorena; S/I; 1031862
dc.information.autorucEscuela de Medicina; Lopez Fuenzalida, Antonio Eduardo; S/I; 1012110
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Irarrazaval Mena, Pablo; 0000-0002-5186-2642; 57376
dc.information.autorucEscuela de Medicina; Galgani Fuentes, Jose Eduardo; 0000-0001-9793-8561; 1011272
dc.language.isoen
dc.publisherFRONTIERS MEDIA SA
dc.revistaFRONTIERS IN NUTRITION
dc.rightsacceso abierto
dc.subjectcarbohydrate metabolism
dc.subjectinsulin sensitivity
dc.subjectinsulin resistance
dc.subjectlipid metabolism
dc.subjectfuel selection
dc.subjectSUBCUTANEOUS ADIPOSE-TISSUE
dc.subjectFATTY-ACID-METABOLISM
dc.subjectBETA-CELL FUNCTION
dc.subjectINSULIN-RESISTANCE
dc.subjectSKELETAL-MUSCLE
dc.subjectOXIDATION
dc.subjectOBESITY
dc.subjectDISPOSAL
dc.subjectINDEXES
dc.subjectCARBOHYDRATE
dc.titleSimilar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test
dc.typeartículo
dc.volumen8
sipa.codpersvinculados1071485
sipa.codpersvinculados1031862
sipa.codpersvinculados1012110
sipa.codpersvinculados57376
sipa.codpersvinculados1011272
sipa.trazabilidadWOS;18-03-2022
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