Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test
dc.catalogador | grr | |
dc.contributor.author | Fernandez Verdejo, Rodrigo Esteban | |
dc.contributor.author | Malo Vintimilla, Maria Lorena | |
dc.contributor.author | Gutierrez Pino, Juan | |
dc.contributor.author | Lopez Fuenzalida, Antonio Eduardo | |
dc.contributor.author | Olmos, Pablo | |
dc.contributor.author | Irarrazaval Mena, Pablo | |
dc.contributor.author | Galgani Fuentes, Jose Eduardo | |
dc.date.accessioned | 2024-05-28T15:02:20Z | |
dc.date.available | 2024-05-28T15:02:20Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Background: Low metabolic flexibility (MetF) may be an underlying factor for metabolic health impairment. Individuals with low MetF are thus expected to have worse metabolic health than subjects with high MetF. Therefore, we aimed to compare metabolic health in individuals with contrasting MetF to an oral glucose tolerance test (OGTT).Methods: In individuals with excess body weight, we measured MetF as the change in respiratory quotient (RQ) from fasting to 1 h after ingestion of a 75-g glucose load (i.e., OGTT). Individuals were then grouped into low and high MetF (Low-MetF n = 12; High-MetF n = 13). The groups had similar body mass index, body fat, sex, age, and maximum oxygen uptake. Metabolic health markers (clinical markers, insulin sensitivity/resistance, abdominal fat, and intrahepatic fat) were compared between groups.Results: Fasting glucose, triglycerides (TG), and high-density lipoprotein (HDL) were similar between groups. So were insulin sensitivity/resistance, visceral, and intrahepatic fat. Nevertheless, High-MetF individuals had higher diastolic blood pressure, a larger drop in TG concentration during the OGTT, and a borderline significant (P = 0.05) higher Subcutaneous Adipose Tissue (SAT). Further, compared to Low-MetF, High-MetF individuals had an about 2-fold steeper slope for the relationship between SAT and fat mass index.Conclusion: Individuals with contrasting MetF to an OGTT had similar metabolic health. Yet High-MetF appears related to enhanced circulating TG clearance and enlarged subcutaneous fat. | |
dc.description.funder | ANID/CONICYT FONDECYT Iniciacion | |
dc.description.funder | ANID/CONICYT FONDECYT | |
dc.fechaingreso.objetodigital | 2024-05-28 | |
dc.format.extent | 11 páginas | |
dc.fuente.origen | WOS | |
dc.identifier.doi | 10.3389/fnut.2021.745907 | |
dc.identifier.issn | 2296-861X | |
dc.identifier.pubmedid | MEDLINE:34869522 | |
dc.identifier.uri | https://doi.org/10.3389/fnut.2021.745907 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/85837 | |
dc.identifier.wosid | WOS:000726110100001 | |
dc.information.autoruc | Departamento de Ciencias de la Salud; Fernandez Verdejo, Rodrigo Esteban; 0000-0002-5948-2281; 1071485 | |
dc.information.autoruc | Escuela de Medicina; Malo Vintimilla, Maria Lorena; S/I; 1031862 | |
dc.information.autoruc | Escuela de Medicina; Lopez Fuenzalida, Antonio Eduardo; S/I; 1012110 | |
dc.information.autoruc | Instituto de Ingeniería Biológica y Médica; Irarrazaval Mena, Pablo; 0000-0002-5186-2642; 57376 | |
dc.information.autoruc | Escuela de Medicina; Galgani Fuentes, Jose Eduardo; 0000-0001-9793-8561; 1011272 | |
dc.language.iso | en | |
dc.publisher | FRONTIERS MEDIA SA | |
dc.revista | FRONTIERS IN NUTRITION | |
dc.rights | acceso abierto | |
dc.subject | carbohydrate metabolism | |
dc.subject | insulin sensitivity | |
dc.subject | insulin resistance | |
dc.subject | lipid metabolism | |
dc.subject | fuel selection | |
dc.subject | SUBCUTANEOUS ADIPOSE-TISSUE | |
dc.subject | FATTY-ACID-METABOLISM | |
dc.subject | BETA-CELL FUNCTION | |
dc.subject | INSULIN-RESISTANCE | |
dc.subject | SKELETAL-MUSCLE | |
dc.subject | OXIDATION | |
dc.subject | OBESITY | |
dc.subject | DISPOSAL | |
dc.subject | INDEXES | |
dc.subject | CARBOHYDRATE | |
dc.title | Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test | |
dc.type | artículo | |
dc.volumen | 8 | |
sipa.codpersvinculados | 1071485 | |
sipa.codpersvinculados | 1031862 | |
sipa.codpersvinculados | 1012110 | |
sipa.codpersvinculados | 57376 | |
sipa.codpersvinculados | 1011272 | |
sipa.trazabilidad | WOS;18-03-2022 |
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