How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member

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dc.catalogadordfo
dc.contributor.authorOpazo, Juan Carlos
dc.contributor.authorVandewege, Michael W.
dc.contributor.authorHoffmann, Federico G.
dc.contributor.authorZavala, Kattina
dc.contributor.authorMelendez, Catalina
dc.contributor.authorLuchsinger, Catalina
dc.contributor.authorCavieres, Viviana A.
dc.contributor.authorVargas-Chacoff, Luis
dc.contributor.authorMorera, Francisco J.
dc.contributor.authorBurgos Hitschfeld, Patricia Verónica
dc.contributor.authorTapia-Rojas, Cheril
dc.contributor.authorMardones, Gonzalo A.
dc.date.accessioned2024-04-03T18:27:11Z
dc.date.available2024-04-03T18:27:11Z
dc.date.issued2023
dc.description.abstractStudying the evolutionary history of gene families is a challenging and exciting task with a wide range of implications. In addition to exploring fundamental questions about the origin and evolution of genes, disentangling their evolution is also critical to those who do functional/structural studies to allow a deeper and more precise interpretation of their results in an evolutionary context. The sirtuin gene family is a group of genes that are involved in a variety of biological functions mostly related to aging. Their duplicative history is an open question, as well as the definition of the repertoire of sirtuin genes among vertebrates. Our results show a well-resolved phylogeny that represents an improvement in our understanding of the duplicative history of the sirtuin gene family. We identified a new sirtuin gene family member (SIRT3.2) that was apparently lost in the last common ancestor of amniotes but retained in all other groups of jawed vertebrates. According to our experimental analyses, elephant shark SIRT3.2 protein is located in mitochondria, the overexpression of which leads to an increase in cellular levels of ATP. Moreover, in vitro analysis demonstrated that it has deacetylase activity being modulated in a similar way to mammalian SIRT3. Our results indicate that there are at least eight sirtuin paralogs among vertebrates and that all of them can be traced back to the last common ancestor of the group that existed between 676 and 615 millions of years ago.
dc.fechaingreso.objetodigital2024-04-03
dc.fuente.origenORCID
dc.identifier.doi10.1093/molbev/msad014
dc.identifier.eissn1537-1719
dc.identifier.pubmedid36656997
dc.identifier.scopusidSCOPUS_ID:85147458192
dc.identifier.urihttps://doi.org/10.1093/molbev/msad014
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84924
dc.information.autorucFacultad de Ciencias Biológicas; Burgos Hitschfeld Patricia Veronica; S/I; 6401
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final18
dc.pagina.inicio1
dc.relation.ispartofMolecular biology and evolution
dc.revistaMolecular biology and evolution
dc.subjectAging
dc.subjectDeacetylase
dc.subjectGene duplication
dc.subjectGene family evolution
dc.subjectMitochondria
dc.subjectSIRT
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.titleHow Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member
dc.typeartículo
dc.volumen40
sipa.codpersvinculados6401
sipa.trazabilidadSCOPUS;02-03-2023
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