The Energy Homeostasis Principle: Neuronal Energy Regulation Drives Local Network Dynamics Generating Behavior

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dc.article.number49
dc.catalogadorpva
dc.contributor.authorVergara, Rodrigo C.
dc.contributor.authorJaramillo-Riveri, Sebastián
dc.contributor.authorLuarte, Alejandro
dc.contributor.authorMoenne Vargas, Cristóbal Matías
dc.contributor.authorFuentes, Rómulo
dc.contributor.authorCouve C., Andrés
dc.contributor.authorMaldonado, Pedro E.
dc.date.accessioned2024-10-18T19:15:46Z
dc.date.available2024-10-18T19:15:46Z
dc.date.issued2019
dc.description.abstractA major goal of neuroscience is understanding how neurons arrange themselves into neural networks that result in behavior. Most theoretical and experimental efforts have focused on a top-down approach which seeks to identify neuronal correlates of behaviors. This has been accomplished by effectively mapping specific behaviors to distinct neural patterns, or by creating computational models that produce a desired behavioral outcome. Nonetheless, these approaches have only implicitly considered the fact that neural tissue, like any other physical system, is subjected to several restrictions and boundaries of operations. Here, we proposed a new, bottom-up conceptual paradigm: The Energy Homeostasis Principle, where the balance between energy income, expenditure, and availability are the key parameters in determining the dynamics of neuronal phenomena found from molecular to behavioral levels. Neurons display high energy consumption relative to other cells, with metabolic consumption of the brain representing 20% of the whole-body oxygen uptake, contrasting with this organ representing only 2% of the body weight. Also, neurons have specialized surrounding tissue providing the necessary energy which, in the case of the brain, is provided by astrocytes. Moreover, and unlike other cell types with high energy demands such as muscle cells, neurons have strict aerobic metabolism. These facts indicate that neurons are highly sensitive to energy limitations, with Gibb's free energy dictating the direction of all cellular metabolic processes. From this activity, the largest energy, by far, is expended by action potentials and post-synaptic potentials; therefore, plasticity can be reinterpreted in terms of their energy context. Consequently, neurons, through their synapses, impose energy demands over post-synaptic neurons in a close loop-manner, modulating the dynamics of local circuits. Subsequently, the energy dynamics end up impacting the homeostatic mechanisms of neuronal networks. Furthermore, local energy management also emerges as a neural population property, where most of the energy expenses are triggered by sensory or other modulatory inputs. Local energy management in neurons may be sufficient to explain the emergence of behavior, enabling the assessment of which properties arise in neural circuits and how. Essentially, the proposal of the Energy Homeostasis Principle is also readily testable for simple neuronal networks.
dc.fechaingreso.objetodigital2024-10-18
dc.format.extent18 páginas
dc.fuente.origenConveris
dc.identifier.doi10.3389/fncom.2019.00049
dc.identifier.issn1662-5188
dc.identifier.pubmedidMEDLINE:31396067
dc.identifier.urihttps://doi.org/10.3389/fncom.2019.00049
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88293
dc.identifier.wosidWOS:000477720800001
dc.information.autorucDepartamento de Ciencias de la Salud; Moenne Vargas, Cristóbal Matías; 0000-0002-9524-2832; 140920
dc.information.autorucFacultad de Ciencias Biológicas; Couve C., Andrés; S/I; 65386
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final18
dc.pagina.inicio1
dc.publisherFrontiers
dc.revistaFrontiers in Computational Neuroscience
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHomeostasis
dc.subjectEnergy
dc.subjectNeuronal networks
dc.subjectBehavior
dc.subjectEmergent properties
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods07 Affordable and clean energy
dc.subject.ods03 Good health and well-being
dc.subject.odspa07 Energía asequible y no contaminante
dc.subject.odspa03 Salud y bienestar
dc.titleThe Energy Homeostasis Principle: Neuronal Energy Regulation Drives Local Network Dynamics Generating Behavior
dc.typeartículo
dc.volumen13
sipa.codpersvinculados207559
sipa.codpersvinculados140920
sipa.codpersvinculados65386
sipa.trazabilidadConveris;20-07-2021
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