Symptomatic Neonatal Arterial Ischemic Stroke: The International Pediatric Stroke Study

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dc.contributor.authorKirton, Adam
dc.contributor.authorArmstrong Wells, Jennifer
dc.contributor.authorChang, Taeun
dc.contributor.authordeVeber, Gabrielle
dc.contributor.authorRivkin, Michael J.
dc.contributor.authorHernandez, Marta
dc.contributor.authorCarpenter, Jessica
dc.contributor.authorYager, Jerome Y.
dc.contributor.authorLynch, John K.
dc.contributor.authorFerriero, Donna M.
dc.contributor.authorInt Pediat Stroke Study
dc.date.accessioned2024-01-10T12:09:02Z
dc.date.available2024-01-10T12:09:02Z
dc.date.issued2011
dc.description.abstractBACKGROUND: Neonatal arterial ischemic stroke (AIS) has emerged as a leading cause of perinatal brain injury, cerebral palsy, and lifelong disability. The pathogenesis is poorly understood, which limits the development of treatment and prevention strategies. Multicenter studies must define epidemiology, risk factors, treatment practices, and outcomes to advance clinical trials and improve the adverse outcomes suffered by most survivors.
dc.description.abstractMETHODS: The International Pediatric Stroke Study is a global research initiative of 149 coinvestigators (30 centers in 10 countries). Patients with clinical and neuroimaging confirmation of symptomatic neonatal AIS were enrolled (2003-2007). Standardized, Web-based data entry collected clinical presentations, risk factors, investigations, treatments, and early outcomes. We examined predictors of infarct characteristics and discharge outcome by using multivariate logistic regression.
dc.description.abstractRESULTS: Two hundred forty-eight neonates were studied (57% male, 10% premature). Most of them presented with seizure (72%) and nonfocal neurologic signs (63%). MRI was completed for 92% of the infants, although <50% had vascular imaging. Infarcts preferentially involved the anterior circulation and left hemisphere and were multifocal in 30%. Maternal health and pregnancies were usually normal. Neonates often required resuscitation (30%) and had systemic illnesses (23%). Cardiac and prothrombotic abnormalities were identified in <20% of the infants. Antithrombotic treatment was uncommon (21%) and varied internationally. Half (49%) of the infants had deficits at discharge, and data on their long-term outcomes are pending.
dc.description.abstractCONCLUSIONS: Newborns with AIS are often systemically sick, whereas their mothers are usually healthy. Definitive causes for most neonatal AISs have not been established, and large-scale case-control studies are required to understand pathogenesis if outcomes are to be improved. Pediatrics 2011;128:e1402-e1410
dc.description.funderChild Neurology Foundation
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1542/peds.2011-1148
dc.identifier.eissn1098-4275
dc.identifier.issn0031-4005
dc.identifier.pubmedidMEDLINE:22123886
dc.identifier.urihttps://doi.org/10.1542/peds.2011-1148
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76452
dc.identifier.wosidWOS:000298131400005
dc.information.autorucMedicina;Hernandez M ;S/I;55673
dc.issue.numero6
dc.language.isoen
dc.nota.accesoSin adjunto
dc.publisherAMER ACAD PEDIATRICS
dc.revistaPEDIATRICS
dc.rightsregistro bibliográfico
dc.subjectstroke
dc.subjectnewborn
dc.subjectperinatal stroke
dc.subjectCEREBRAL SINOVENOUS THROMBOSIS
dc.subjectPERINATAL STROKE
dc.subjectRISK-FACTORS
dc.subjectCHILDREN
dc.subjectDISORDERS
dc.subjectINFANTS
dc.subjectINFARCTION
dc.subjectDIAGNOSIS
dc.subjectNEWBORN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSymptomatic Neonatal Arterial Ischemic Stroke: The International Pediatric Stroke Study
dc.typeartículo
dc.volumen128
sipa.codpersvinculados55673
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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