Presence of Bordetella holmesii in an outbreak of pertussis in Chile

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dc.contributor.authorMiranda, Carolina
dc.contributor.authorWozniak, Aniela
dc.contributor.authorCastillo, Claudia
dc.contributor.authorGeoffroy, Enrique
dc.contributor.authorZumaran, Cecilia
dc.contributor.authorPorte, Lorena
dc.contributor.authorRoman, Juan C.
dc.contributor.authorPotin, Marcela
dc.contributor.authorGarcia, Patricia
dc.date.accessioned2024-01-10T13:16:30Z
dc.date.available2024-01-10T13:16:30Z
dc.date.issued2013
dc.description.abstractThe incidence of whooping cough in Chile ranges from 4.1 and 7.5 per hundred thousand inhabitants. B. pertussis detection is performed by Real Time PCR (Q-PCR) directed to the insertion sequence IS481. However, this sequence is also found in the genome of B. bronchiseptica and B. holmesii. The latter is also a respiratory pathogen whose clinical features are similar to B. pertussis. However, it is important to differentiate between these species because in immunosuppressed patients B. holmesii is more likely to cause bacteremia and is less susceptible to erythromycin. The goal of this work is to measure prospectively and retrospectively the presence of B. holmesii in samples reported positive for B. pertussis in the period 2010-2011. During this period, 1994 nasopharyngeal specimens entered the laboratory for Bordetella sp. PCR, of which 224 were positive. The analysis by Q-PCR directed to the recA gene of B. holmesii of all 224 positive samples determined a prevalence of B. holmesii of 0.6% (12/1994). Because of its more aggressive behavior in immunosupressed patients and its different resistance pattern, routine screening of B. pertussis and B. holmesii is currently performed for all samples in which Bordetella sp PCR is initially detected.
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.eissn0717-6341
dc.identifier.issn0716-1018
dc.identifier.pubmedidMEDLINE:23877774
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78590
dc.identifier.wosidWOS:000320345400001
dc.information.autorucMedicina;Castillo C;S/I;117026
dc.information.autorucMedicina;Garcia P;S/I;73909
dc.information.autorucMedicina;Geoffroy E;S/I;1008340
dc.information.autorucMedicina;Miranda C;S/I;1002889
dc.information.autorucMedicina;Porte L;S/I;1006794
dc.information.autorucMedicina;Potin M;S/I;64027
dc.information.autorucMedicina;Roman J;S/I;117336
dc.information.autorucMedicina;Wozniak A;S/I;1008612
dc.issue.numero3
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final243
dc.pagina.inicio237
dc.publisherSOC CHILENA INFECTOLOGIA
dc.revistaREVISTA CHILENA DE INFECTOLOGIA
dc.rightsregistro bibliográfico
dc.subjectBordetella holmesii
dc.subjectinsertion sequence IS481
dc.subjectpolymerase chain reaction
dc.subjectdiagnosis
dc.subjectTIME PCR ASSAY
dc.subjectPOLYMERASE-CHAIN-REACTION
dc.subjectINFECTIONS
dc.subjectSYMPTOMS
dc.subjectIS481
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePresence of Bordetella holmesii in an outbreak of pertussis in Chile
dc.typeartículo
dc.volumen30
sipa.codpersvinculados117026
sipa.codpersvinculados73909
sipa.codpersvinculados1008340
sipa.codpersvinculados1002889
sipa.codpersvinculados1006794
sipa.codpersvinculados64027
sipa.codpersvinculados117336
sipa.codpersvinculados1008612
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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