Melatonin and Inflammatory Cytokines as Modulators of the Interaction Between Gestational Diabetes Mellitus and Pregnancy-Specific Urinary Incontinence

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dc.catalogadorjlo
dc.contributor.authorHonório França, Danielle Cristina
dc.contributor.authorFrança, Eduardo Luzia
dc.contributor.authorHonório-França, Adenilda Cristina
dc.contributor.authorRezende Silva, Kênia Maria
dc.contributor.authorAtaídes de Queiroz, Adriele
dc.contributor.authorMorais, Tassiane Cristina
dc.contributor.authorHonorio França, Emanuelle Carolina
dc.contributor.authorFrota de Carvalho, Carolina Neiva
dc.contributor.authorGomes Fagundes-Triches, Danny Laura
dc.contributor.authorPascon Barbosa, Angélica Mércia
dc.contributor.authorParanhos Calderon, Iracema de Mattos
dc.contributor.authorSobrevia Luarte, Luis Alberto
dc.contributor.authorCunha Rudge, Marilza Vieira
dc.date.accessioned2025-11-06T18:59:12Z
dc.date.available2025-11-06T18:59:12Z
dc.date.issued2025
dc.description.abstractBackground: The pathogenesis of developing gestational diabetes mellitus (GDM) integrated with pregnancy-specific urinary incontinence (PSUI) may be related to immunological and hormonal factors. Inflammatory cytokines influence the function and regulation of the urinary tract, and changes in melatonin concentration are a predisposing factor for smooth muscle dysfunction and cystometric changes. Objective: This study examines the influence of melatonin, MT1 and MT2 receptors, and inflammatory cytokines in the blood and urine of pregnant women with GDM and PSUI. Methods: Two hundred sixty-nine pregnant women were approached during the diagnostic investigation of GDM and answered a specifically structured questionnaire about the involuntary loss of urine. According to these criteria, mothers were divided into four groups: continent normoglycemic (NG-C), incontinent normoglycemic (NG-I), continent GDM (GDM-C), and incontinent GDM (GDM-UI). Blood and urine samples were collected to determine the levels of melatonin, melatonin sulfate, melatonin receptors (MT1 and MT2), and inflammatory cytokines. Results: Blood level of melatonin and IL-10 was lower, but MT1, MT2, IL-1β, IL-8, and TNF-α were higher in GDM-UI compared with the NG-C group. The melatonin sulfate level was lower in the urine of the GDM-UI group compared with the NG-C group. Conclusions: Maternal hyperglycemia associated with urinary incontinence generates an inflammatory environment characterized by reduced melatonin and IL-10 and increased IL-1β, IL-8, and TNF-α in the blood of mothers with GDM with UI. This environmental condition may be involved in the pathogenesis of these pathologies.
dc.fechaingreso.objetodigital2025-11-06
dc.format.extent16 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/metabo15110699
dc.identifier.issn2218-1989
dc.identifier.urihttps://doi.org/10.3390/metabo15110699
dc.identifier.urihttps://www.mdpi.com/2218-1989/15/11/699
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/106568
dc.information.autorucEscuela de Medicina; Sobrevia Luarte, Luis Alberto; 0000-0001-5802-2243; 1002656
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaMetabolites
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNeuropharmacology
dc.subjectHormones
dc.subjectHyperglycemia
dc.subjectInvoluntary loss of urine
dc.subjectHormone receptor
dc.subjectImmunomodulation
dc.subjectGestation
dc.subjectDiabetes
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMelatonin and Inflammatory Cytokines as Modulators of the Interaction Between Gestational Diabetes Mellitus and Pregnancy-Specific Urinary Incontinence
dc.typeartículo
dc.volumen15
sipa.codpersvinculados1002656
sipa.trazabilidadORCID;2025-11-03
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