Relationship of emphysema and airway disease assessed by CT to exercise capacity in COPD

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dc.contributor.authorDiaz, Alejandro A.
dc.contributor.authorBartholmai, Brian
dc.contributor.authorEstepar, Raul San Jose
dc.contributor.authorRoss, James
dc.contributor.authorMatsuoka, Shin
dc.contributor.authorYamashiro, Tsuneo
dc.contributor.authorHatabu, Hiroto
dc.contributor.authorReilly, John J.
dc.contributor.authorSilverman, Edwin K.
dc.contributor.authorWashko, George R.
dc.date.accessioned2024-01-10T12:42:03Z
dc.date.available2024-01-10T12:42:03Z
dc.date.issued2010
dc.description.abstractObjective: To assess the association of emphysema and airway disease assessed by volumetric computed tomography (CT) with exercise capacity in subjects with chronic obstructive pulmonary disease (COPD).
dc.description.abstractMethods: We studied 93 subjects with COPD (Forced Expiratory Volume in 1 s [FEV1] %predicted mean SD 57.1 + 24.3%, female gender = 40) enrolled in the Lung Tissue Research Consortium. Emphysema was defined as percentage of low attenuation areas less than a threshold of 950 Hounsfield units (%LAA-950) on CT scan. The wall area percentage (WA%) of the 3rd to 6th generations of the apical bronchus of right upper lobe (RI31) were analyzed. The 6-min walk distance (6MWD) test was used as a measure of exercise capacity.
dc.description.abstractResults: The 6MWD was inversely associated with %LAA-950 (r = 0.53, p < 0.0001) and with the WA% of 6th generation of RBI only (r = 0.28, p = 0.009). In a multivariate regression model including CT indices of emphysema and airway disease that were adjusted for demographic and physiologic variables as well as brand of CT scanner, only the %LAA-950 remained significantly associated with exercise performance. Holding other covariates fixed, this model showed that a 10% increase of CT emphysema reduced the distance walked in 6 min 28.6 m (95% Confidence Interval = -51.2, -6.0, p = 0.01).
dc.description.abstractConclusion: These results suggest that the extent of emphysema but not airway disease measured by volumetric CT contributes independently to exercise limitation in subjects with COPD. (C) 2010 Elsevier Ltd. All rights reserved.
dc.description.funderGlaxoSmithKline
dc.description.funderAstraZeneca
dc.description.funderNational Institutes of Health
dc.description.funderParker B. Francis Foundation
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.fechaingreso.objetodigital17-04-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.rmed.2010.02.023
dc.identifier.eissn1532-3064
dc.identifier.issn0954-6111
dc.identifier.pubmedidMEDLINE:20385477
dc.identifier.urihttps://doi.org/10.1016/j.rmed.2010.02.023
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77476
dc.identifier.wosidWOS:000280178900008
dc.information.autorucMedicina;Díaz AA;S/I;104496
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1151
dc.pagina.inicio1145
dc.publisherW B SAUNDERS CO LTD
dc.revistaRESPIRATORY MEDICINE
dc.rightsacceso restringido
dc.subjectCOPD
dc.subjectCT
dc.subjectEmphysema
dc.subjectAirways
dc.subject6-min walk test
dc.subjectQUALITY-OF-LIFE
dc.subjectWALL THICKNESS
dc.subjectCOMPUTED-TOMOGRAPHY
dc.subjectREFERENCE EQUATIONS
dc.subjectFLOW LIMITATION
dc.subjectDENSITY MASK
dc.subjectDIMENSIONS
dc.subjectSMOKERS
dc.subjectPERFORMANCE
dc.subjectMECHANISMS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRelationship of emphysema and airway disease assessed by CT to exercise capacity in COPD
dc.typeartículo
dc.volumen104
sipa.codpersvinculados104496
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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