The clinical significance of eosinophils in the amniotic fluid in preterm labor

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dc.contributor.authorRomero, Roberto
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorGomez, Ricardo
dc.contributor.authorLamont, Ronald
dc.contributor.authorBytautiene, Egle
dc.contributor.authorGarfield, Robert E.
dc.contributor.authorMittal, Pooja
dc.contributor.authorHassan, Sonia S.
dc.contributor.authorYeo, Lami
dc.date.accessioned2024-01-10T13:43:46Z
dc.date.available2024-01-10T13:43:46Z
dc.date.issued2010
dc.description.abstractMethods. This retrospective case-control study included women who presented with preterm labor and intact membranes between 24 and 34 weeks of gestation. Patients underwent an amniocentesis shortly after admission for the assessment of the microbiologic status of the amniotic cavity and/or fetal lung maturity. Amniotic fluid was cultured for aerobic and anaerobic bacteria as well as genital mycoplasmas. Cytologic studies included amniotic fluid white blood cell count and differential, which was performed on cytocentrifuged specimens. Patients with microbial invasion of the amniotic cavity and/or an amniotic fluid white blood cell count > 20 cells/mm<SU3</SU were excluded from the study. Cases were defined as women in whom the differential contained > 20% of eosinophils. Controls were selected among women with an amniotic fluid eosinophil count < 20% and matched for gestational age at amniocentesis. The analysis was conducted with non-parametric statistics.
dc.description.abstractResults. The study population consisted of 10 cases and 50 controls. Gestational age and cervical dilatation at admission were similar in both groups. Cases had a lower gestational age at delivery than controls [34.6 weeks, inter-quartile range (IQR) 32-37.3 weeks vs. 38.0 weeks, IQR 35-40 weeks, respectively; p = 0.018]. The prevalence of preterm delivery < 35 weeks was higher among patients who had > 20% eosinophils than in the control group [50% (5/10) vs. 18% (9/50), respectively; p = 0.029]. Similar results were observed for delivery at < 37 weeks [cases: 70% (7/10) vs. controls: 36% (18/50); p = 0.046].
dc.description.abstractConclusions. Women with preterm labor and intact membranes who have a large proportion of eosinophils in the amniotic fluid are at an increased risk for spontaneous preterm delivery. These patients may have had an episode of preterm labor related to a type I hypersensitivity reaction.
dc.description.funderPerinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/14767050903168465
dc.identifier.eissn1476-4954
dc.identifier.issn1476-7058
dc.identifier.pubmedidMEDLINE:19900034
dc.identifier.urihttps://doi.org/10.3109/14767050903168465
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78749
dc.identifier.wosidWOS:000275470600010
dc.information.autorucMedicina;Gómez R;S/I;80926
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final329
dc.pagina.inicio320
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
dc.rightsacceso restringido
dc.subjectPremature birth
dc.subjectpreterm birth
dc.subjectprematurity
dc.subjectpremature labor
dc.subjectmast cells
dc.subjectamniotic fluid cells
dc.subjectamniotic fluid white
dc.subjectblood cells
dc.subjectallergy
dc.subjectallergy-induced preterm labor
dc.subjectatopy
dc.subjectpregnancy
dc.subjecttype I hypersensitivity reaction
dc.subjectparturition
dc.subjectlabor
dc.subjecteosinophil granule proteins
dc.subjectMAJOR BASIC-PROTEIN
dc.subjectULTRASONOGRAPHIC CERVICAL LENGTH
dc.subjectENDOTHELIAL GROWTH-FACTOR
dc.subjectCOLONY-STIMULATING FACTOR
dc.subjectPREMATURE RUPTURE
dc.subjectINTRAAMNIOTIC INFLAMMATION
dc.subjectAIRWAYS HYPERREACTIVITY
dc.subjectDIFFERENTIATION FACTOR
dc.subjectHUMAN INTERLEUKIN-5
dc.subjectMICROBIAL INVASION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe clinical significance of eosinophils in the amniotic fluid in preterm labor
dc.typeartículo
dc.volumen23
sipa.codpersvinculados80926
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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