Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j]phenanthridine- and Benzo[g]pyrimido[4,5-c]isoquinolinequinones

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dc.contributor.authorIribarra, Jennyfer
dc.contributor.authorVasquez, David
dc.contributor.authorTheoduloz, Cristina
dc.contributor.authorBenites, Julio
dc.contributor.authorRios, David
dc.contributor.authorValderrama, Jaime A.
dc.date.accessioned2024-01-10T12:43:17Z
dc.date.available2024-01-10T12:43:17Z
dc.date.issued2012
dc.description.abstractA variety of novel 6-arylsubstituted benzo[j]phenanthridine-and benzo[g]pyrimido[4,5-c]isoquinolinequinones were synthesized from 1,4-naphthoquinone, aryl-aldehydes and enaminones via a two-step synthetic approach. The cytotoxic activity of the aminoquinone derivatives was evaluated in vitro against one normal cell line (MRC-5 lung fibroblasts) and three human cancer cell lines (AGS human gastric adenocarcinoma; SK-MES-1 human lung cancer cells, and J82 human bladder carcinoma) in 72-h drug exposure assays using the MTT colorimetric method. Structure-activity relationships within the series of angular quinones reveal that the insertion of pyrrol-2-yl and furan-2-yl groups at the 6-position is more significant for the increase of the potency and selectivity index of the pharmacophores.
dc.description.funderFondo Nacional de Ciencia y Tecnologia
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent14 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3390/molecules171011616
dc.identifier.issn1420-3049
dc.identifier.pubmedidMEDLINE:23023687
dc.identifier.urihttps://doi.org/10.3390/molecules171011616
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77581
dc.identifier.wosidWOS:000310505400023
dc.information.autorucQuímica; Valderrama J;S/I;98772
dc.issue.numero10
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final11629
dc.pagina.inicio11616
dc.publisherMDPI
dc.revistaMOLECULES
dc.rightsacceso abierto
dc.subjectN-heterocyclic quinones
dc.subjectenaminones
dc.subjectcytotoxicity
dc.subjectSAR analysis
dc.subjectCELL-LINES
dc.subjectCYTOTOXICITY
dc.subjectASSAY
dc.subjectDNA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j]phenanthridine- and Benzo[g]pyrimido[4,5-c]isoquinolinequinones
dc.typeartículo
dc.volumen17
sipa.codpersvinculados98772
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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