DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA 1 promoter region in early-onset gastric carcinogenesis

Simple item page
dc.contributor.authorBernal, Carolina
dc.contributor.authorVargas, Macarena
dc.contributor.authorOssandon, Francisco
dc.contributor.authorSantibanez, Eudocia
dc.contributor.authorUrrutia, Julio
dc.contributor.authorLuengo, Victor
dc.contributor.authorZavala, Luis F.
dc.contributor.authorBackhouse, Claudia
dc.contributor.authorPalma, Mariana
dc.contributor.authorArgandona, Jorge
dc.contributor.authorAguayo, Francisco
dc.contributor.authorCorvalan, Alejandro
dc.date.accessioned2024-01-10T13:12:25Z
dc.date.available2024-01-10T13:12:25Z
dc.date.issued2008
dc.description.abstractDiffuse type gastric carcinoma is the most aggressive type of gastric cancer. This type Of tumor is not preceded by precancerous changes and is associated with carly-onset and hereditary syndromes. To test the hypothesis that DNA methylation profile Would be useful for molecular classification of the diffuse type gastric carcinoma, DNA methylation patterns of the CpG Island of 17 genes were studied in 104 cases and 47 normal adjacent gastric mucosa by Methylation-specific PCR, Immunohistochemistry and Hierarchical Clustering analysis. The most frequent methylated genes were FHIT, E-cadherin, BRCA1 and APC (>50%), followed by p14, p16, p15, p73, MGMT and SEMA3B (20-49%). Hierarchical clustering analysis reveals four groups with different clinical features. The first was characterized by hypermethylation of BRCA 1 and younger age (<45 years old), and the second by hypermethylation of p14 and p 16 genes, male. predominance and Epstein-Barr virus infection. The third group was characterized by hypermethylation of FHIT and antrum located tumors and the fourth was not associated with any clinical variables. In normal adjacent mucosa only the p73 gene was significantly less methylated in comparison to tumor mucosa. DNA methylation identified subgroups of diffuse type gastric cancer. Hypermethylation of BRCA I associated with Young age suggests a role in early-onset gastric carcinoma.
dc.description.funderFONDECYT
dc.description.funderChilean government
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.eissn0717-6287
dc.identifier.issn0716-9760
dc.identifier.pubmedidMEDLINE:19399343
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78183
dc.identifier.wosidWOS:000262306100007
dc.information.autorucMedicina;Aguayo F;S/I;1005475
dc.information.autorucMedicina;Bernal C;S/I;1003963
dc.information.autorucMedicina;Corvalán A;S/I;63885
dc.information.autorucMedicina;Luengo V;S/I;132729
dc.information.autorucMedicina;Santibáñez E;S/I;1004649
dc.information.autorucMedicina;Urrutia J;S/I;69910
dc.information.autorucMedicina;Zavala L;S/I;132738
dc.issue.numero3
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final315
dc.pagina.inicio303
dc.publisherSOC BIOLGIA CHILE
dc.revistaBIOLOGICAL RESEARCH
dc.rightsregistro bibliográfico
dc.subjectgastric cancer
dc.subjectdiffuse type
dc.subjectearly-onset
dc.subjectBRCA-1
dc.subjectCPG ISLAND METHYLATION
dc.subjectEPSTEIN-BARR-VIRUS
dc.subjectTUMOR-SUPPRESSOR GENES
dc.subjectSIGNET-RING CELL
dc.subjectGALLBLADDER CARCINOMA
dc.subjectABERRANT METHYLATION
dc.subjectMULTIPLE GENES
dc.subjectOVARIAN-CANCER
dc.subjectEXPRESSION
dc.subjectPROGRESSION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA 1 promoter region in early-onset gastric carcinogenesis
dc.typeartículo
dc.volumen41
sipa.codpersvinculados1005475
sipa.codpersvinculados1003963
sipa.codpersvinculados63885
sipa.codpersvinculados132729
sipa.codpersvinculados1004649
sipa.codpersvinculados69910
sipa.codpersvinculados132738
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
DNA methylation profile in diffuse type gastric cancer; evidence for hypermethylation of the BRCA 1 promoter region in early-onset gastric carcinogenesis.pdf
Size:
2.85 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas