High impulsive choice is accompanied by an increase in dopamine release in rat dorsolateral striatum

Simple item page
dc.article.number113199
dc.catalogadorjlo
dc.contributor.authorMoreno Fernández, Macarena Gipsy
dc.contributor.authorAzócar Garrido, Víctor Hugo
dc.contributor.authorVerges Gómez, Álvaro Javier
dc.contributor.authorFuentealba Evans, José Antonio
dc.date.accessioned2023-09-26T19:07:32Z
dc.date.available2023-09-26T19:07:32Z
dc.date.issued2021
dc.description.abstractDopamine neurotransmission has been consistently associated with individual differences in impulsive choice. Clinical and preclinical evidence suggests that low striatal dopamine D2 signaling predisposes to engage in impulsive behaviors. Although dopamine D2 signaling controls dopamine (DA) extracellular levels, the relationship between striatal dopamine extracellular levels and impulsive choice remains poorly understood. Using quantitative microdialysis, we investigated whether extracellular DA levels in rat dorsolateral striatum (DLS) correlates with preference for an immediate small reward or for a delayed larger reward. Rats were tested in a delay-discounting task and classified as high impulsive (HI) or low impulsive (LI) according to the area under the discounting curve (AUC). No-net flux microdialysis experiments, assessing basal DA release, DA-uptake, and DA extracellular concentration (DA Cext), were carried out in dorsolateral striatum (DLS) of urethane-anesthetized rats. Rats classified as HI showed a higher DA release compared with LI rats. Differences in DLS DA-uptake and DA Cext were non-significant. Importantly, a significant negative correlation was observed between AUC and DA release, indicating that the lower the AUC, the higher the DLS DA release. This finding shows that DA release is augmented in the DLS of rats classified as HI, suggesting that a hyper-activated nigro-striatal pathway contributes to impulsive choice.
dc.fechaingreso.objetodigital2023-09-26
dc.format.extent9 páginas
dc.fuente.origenSIPA
dc.identifier.doi10.1016/j.bbr.2021.113199
dc.identifier.issn0166-4328
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2021.113199
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74704
dc.information.autorucEscuela de Medicina; Moreno Fernández, Macarena Gipsy; 0000-0001-5954-0675; 249993
dc.information.autorucEscuela de Química; Azócar Garrido, Víctor Hugo; S/I; 195190
dc.information.autorucEscuela de Psicología; Verges Gómez, Álvaro Javier; 0000-0002-5138-1312; 165712
dc.information.autorucEscuela de Química; Fuentealba Evans, José Antonio; 0000-0003-0775-0675; 7207
dc.issue.numero405
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final9
dc.pagina.inicio1
dc.revistaBehavioural Brain Research
dc.rightsacceso restringido
dc.subjectDelay discounting task
dc.subjectImpulsive choice
dc.subjectDorsolateral striatum
dc.subjectDopamine
dc.subjectNo-net flux microdialysis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleHigh impulsive choice is accompanied by an increase in dopamine release in rat dorsolateral striatum
dc.typeartículo
sipa.codpersvinculados249993
sipa.codpersvinculados195190
sipa.codpersvinculados165712
sipa.codpersvinculados7207
sipa.trazabilidadORCID;25-03-2022
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
High impulsive choice is accompanied by an increase.pdf
Size:
78.04 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas