Crosstalk Between Epithelial Cells, Neurons and Immune Mediators in HSV-1 Skin Infection

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dc.catalogadorjlo
dc.contributor.authorDuarte Peñaloza, Luisa Fernanda
dc.contributor.authorReyes Muñoz, Antonia
dc.contributor.authorFarías León, Mónica
dc.contributor.authorRiedel Soria, Claudia
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorKalergis Parra, Alexis
dc.contributor.authorGonzález Adonis, Pablo Andrés
dc.date.accessioned2024-01-29T17:48:31Z
dc.date.available2024-01-29T17:48:31Z
dc.date.issued2021
dc.description.abstractHerpes simplex virus type 1 (HSV-1) infection is highly prevalent in humans, with approximately two-thirds of the world population living with this virus. However, only a fraction of those carrying HSV-1, which elicits lifelong infections, are symptomatic. HSV-1 mainly causes lesions in the skin and mucosae but reaches the termini of sensory neurons innervating these tissues and travels in a retrograde manner to the neuron cell body where it establishes persistent infection and remains in a latent state until reactivated by different stimuli. When productive reactivations occur, the virus travels back along axons to the primary infection site, where new rounds of replication are initiated in the skin, in recurrent or secondary infections. During this process, new neuron infections occur. Noteworthy, the mechanisms underlying viral reactivations and the exit of latency are somewhat poorly understood and may be regulated by a crosstalk between the infected neurons and components of the immune system. Here, we review and discuss the immune responses that occur at the skin during primary and recurrent infections by HSV-1, as well as at the interphase of latently-infected neurons. Moreover, we discuss the implications of neuronal signals over the priming and migration of immune cells in the context of HSV-1 infection.
dc.fechaingreso.objetodigital2024-05-16
dc.fuente.origenORCID-ene24
dc.identifier.doi10.3389/fimmu.2021.662234
dc.identifier.issn1664-3224
dc.identifier.urihttp://dx.doi.org/10.3389/fimmu.2021.662234
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81034
dc.information.autorucFacultad de Ciencias Biológicas; Duarte Peñaloza Luisa Fernanda; 0000-0003-1828-1800; 1031205
dc.information.autorucFacultad de Ciencias Biológicas; Reyes Muñoz Antonia Paz; 0000-0002-0334-7902; 247419
dc.information.autorucFacultad de Ciencias Biológicas; Farias Leon Monica Andrea; 0000-0003-0550-2002; 205467
dc.information.autorucFacultad de Ciencias Biológicas; Riedel Soria, Claudia; 0000-0001-6168-8601; 88772
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan Marcela; 0000-0002-7551-8088; 113541
dc.information.autorucEscuela de Medicina; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucEscuela de Psicología; González Adonis, Pablo Andrés; 0000-0001-7523-5363; 133334
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final16
dc.pagina.inicio1
dc.revistaFrontiers in Immunology
dc.rightsacceso abierto
dc.subjectHSV-1
dc.subjectImmune system
dc.subjectNervous system
dc.subjectneuropeptides
dc.subjectskin
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleCrosstalk Between Epithelial Cells, Neurons and Immune Mediators in HSV-1 Skin Infection
dc.typeartículo
dc.volumen12
sipa.codpersvinculados1031205
sipa.codpersvinculados247419
sipa.codpersvinculados205467
sipa.codpersvinculados88772
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.codpersvinculados133334
sipa.trazabilidadORCID;2024-01-15
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