Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions

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dc.catalogadorpva
dc.contributor.authorOrellana Roca, Juan Andrés
dc.contributor.authorFigueroa, Xavier
dc.contributor.authorSánchez Riquelme, Helmuth Alberto
dc.contributor.authorContreras Duarte, Susana de las Mercedes
dc.contributor.authorVelarde Aliaga, María Victoria
dc.contributor.authorSáez, Juan Carlos
dc.date.accessioned2024-10-14T19:40:27Z
dc.date.available2024-10-14T19:40:27Z
dc.date.issued2011
dc.description.abstractIn the normal brain, cellular types that compose the neurovascular unit, including neurons, astrocytes and endothelial cells express pannexins and connexins, which are protein subunits of two families that form plasma membrane channels. Most available evidence in mammals indicated that endogenously expressed pannexins only form hemichannels, and connexins form both gap junction channels and hemichannels. While gap junction channels connect the cytoplasm of contacting cells and coordinate electrical and metabolic activities, hemichannels communicate intra- and extracellular compartments and serve as diffusional pathways for ions and small molecules. Here, evidence supporting the functional role of hemichannels in the neurovascular unit and white matter under physiological and pathological conditions are reviewed. A sub-threshold acute pathological threatening condition ( e. g., stroke and brain infection) leads to glial cell activation, which maintains an active defense and restores the normal function of the neurovascular unit. However, if the stimulus is deleterious, microglia and the endothelium become overactivated, both releasing bioactive molecules ( e. g., glutamate, cytokines, prostaglandins and ATP) that increase the activity of astroglial hemichannels, reducing the astrocyte neuroprotective functions, and further reducing neuronal cell viability. Moreover, ATP is known to contribute to myelin degeneration of axons. Consequently, hemichannels might play a relevant role in the excitotoxic response of oligodendrocytes observed in ischemia and encephalomyelitis. Regulated changes in hemichannel permeability in healthy brain cells can have positive consequences in terms of paracrine/autocrine signaling, whereas persistent changes in cells affected by neurological disorders can be detrimental. Therefore, blocking hemichannels expressed by glial cells and/or neurons of the inflamed central nervous system might prevent neurovascular unit dysfunction and neurodegeneration.
dc.description.funderFONDECYT
dc.fuente.origenHistorial Académico
dc.identifier.doi10.2174/187152711794653869
dc.identifier.eissn1996-3181
dc.identifier.issn1871-5273
dc.identifier.pubmedidPMID: 21288190
dc.identifier.urihttps://doi.org/10.2174/187152711794653869
dc.identifier.urihttps://publons.com/wos-op/publon/11458588/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88205
dc.identifier.wosidWOS:000290613100015
dc.information.autorucFacultad de Ciencias Biológicas; Orellana Roca, Juan Andrés; 0000-0003-4076-207X; 126007
dc.information.autorucFacultad de Ciencias Biológicas; Figueroa, Xavier; 0000-0001-9656-9100; 1437
dc.information.autorucFacultad de Ciencias Biológicas; Sánchez Riquelme, Helmuth Alberto; S/I; 12317
dc.information.autorucFacultad de Ciencias Biológicas; Contreras Duarte, Susana de las Mercedes; 0000-0002-4198-7011; 149705
dc.information.autorucFacultad de Ciencias Biológicas; Velarde Aliaga, María Victoria; S/I; 55362
dc.information.autorucFacultad de Ciencias Biológicas; Sáez, Juan Carlos; 0000-0003-3811-0347; 99913
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final414
dc.pagina.inicio404
dc.revistaCNS and Neurological Disorders - Drug Targets
dc.rightsacceso restringido
dc.subjectCerebral vasculature
dc.subjectConnexins
dc.subjectGlial cells
dc.subjectInflammation
dc.subjectMyelination
dc.subjectPannexins
dc.subjectTripartite synapse
dc.subjectHemichannels
dc.subjectCharcot-Marie-Tooth Disease
dc.subjectCMTX
dc.subjectLipopolysaccharide
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions
dc.typeartículo
dc.volumen10
sipa.codpersvinculados126007
sipa.codpersvinculados1437
sipa.codpersvinculados12317
sipa.codpersvinculados149705
sipa.codpersvinculados55362
sipa.codpersvinculados99913
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadConveris;20-07-2021
sipa.trazabilidadORCID;2024-10-14
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