Induction of trained immunity by recombinant vaccines

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dc.article.number611946
dc.catalogadorpva
dc.contributor.authorCovián, Camila
dc.contributor.authorRios Raggio, Mariana
dc.contributor.authorBerríos Rojas, Roslye V.
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.date.accessioned2024-01-23T19:43:51Z
dc.date.available2024-01-23T19:43:51Z
dc.date.issued2020
dc.description.abstractVaccines represent an important strategy to protect humans against a wide variety of pathogens and have even led to eradicating some diseases. Although every vaccine is developed to induce specific protection for a particular pathogen, some vaccine formulations can also promote trained immunity, which is a non-specific memory-like feature developed by the innate immune system. It is thought that trained immunity can protect against a wide variety of pathogens other than those contained in the vaccine formulation. The non-specific memory of the trained immunity-based vaccines (TIbV) seems beneficial for the immunized individual, as it may represent a powerful strategy that contributes to the control of pathogen outbreaks, reducing morbidity and mortality. A wide variety of respiratory viruses, including respiratory syncytial virus (hRSV) and metapneumovirus (hMPV), cause serious illness in children under 5 years old and the elderly. To address this public health problem, we have developed recombinant BCG vaccines that have shown to be safe and immunogenic against hRSV or hMPV. Besides the induction of specific adaptive immunity against the viral antigens, these vaccines could generate trained immunity against other respiratory pathogens. Here, we discuss some of the features of trained immunity induced by BCG and put forward the notion that recombinant BCGs expressing hRSV or hMPV antigens have the capacity to simultaneously induce specific adaptive immunity and non-specific trained immunity. These recombinant BCG vaccines could be considered as TIbV capable of inducing simultaneously the development of specific protection against hRSV or hMPV, as well as non-specific trained-immunity-based protection against other pathogenic viruses.
dc.description.funderCONICYT
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-01-23
dc.fuente.origenScopus
dc.identifier.doi10.3389/fimmu.2020.611946
dc.identifier.eissn16643224
dc.identifier.issn1664-3224
dc.identifier.pubmedid33584692
dc.identifier.scopusidSCOPUS_ID:85099731315
dc.identifier.urihttps://doi.org/10.3389/fimmu.2020.611946
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80925
dc.identifier.wosidWOS:000609126000001
dc.information.autorucFacultad de Ciencias Biológicas; Rios Raggio, Mariana; S/I; 50388
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final9
dc.pagina.inicio1
dc.publisherFrontiers Media S.A.
dc.revistaFrontiers in Immunologyes_ES
dc.rightsacceso abierto
dc.rights.licenseCreative Commons Attribution License (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectRecombinant BCGes_ES
dc.subjectTrained immunityes_ES
dc.subjectUnspecific cross-protectiones_ES
dc.subjectRespiratory syncytial viruses_ES
dc.subjectMetapneumoviruses_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInduction of trained immunity by recombinant vaccineses_ES
dc.typeartículo de revisión
dc.volumen11
sipa.codpersvinculados50388
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.trazabilidadScopus;12-10-2021
sipa.trazabilidadORCID;2024-01-15
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