Sonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells

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dc.contributor.authorMartinez, C.
dc.contributor.authorSmith, P. C.
dc.contributor.authorRodriguez, J. P.
dc.contributor.authorPalma, V.
dc.date.accessioned2024-01-10T12:42:49Z
dc.date.available2024-01-10T12:42:49Z
dc.date.issued2011
dc.description.abstractRegulation of cell renewal in the periodontium is a critical cell function that has not been clarified. Sonic hedgehog (Shh) is a secreted signaling molecule that plays a key role during development and adult tissue homeostasis. In the present study, we have analyzed the role played by Shh in human periodontal ligament stem cell (HPLSC) proliferation. HPLSC were isolated with anti-STRO-1 antibodies. Shh increased the expression of GLI1 and PTC-1 and selectively stimulated cell proliferation in STRO-1(+) derived from adult periodontal ligament. Shh components were localized to primary cilia in STRO-1(+) cells after Shh stimulation. STRO-1(+) also expressed Shh, suggesting an autocrine-regulated phenomenon. Thus, we propose that Shh plays a critical role in the regulation of cell proliferation in STRO-1(+)/HPLSC.
dc.description.funderCONICYT
dc.description.funderICM-CGC
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-05-20
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1177/0022034510391797
dc.identifier.eissn1544-0591
dc.identifier.issn0022-0345
dc.identifier.pubmedidMEDLINE:21441223
dc.identifier.urihttps://doi.org/10.1177/0022034510391797
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77544
dc.identifier.wosidWOS:000288798600014
dc.information.autorucMedicina;Martinez C ;S/I;1008613
dc.information.autorucMedicina;Smith PC ;S/I;1006488
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final488
dc.pagina.inicio483
dc.publisherSAGE PUBLICATIONS INC
dc.revistaJOURNAL OF DENTAL RESEARCH
dc.rightsacceso restringido
dc.subjecthuman periodontal ligament stem cells
dc.subjectSonic hedgehog
dc.subjectproliferation
dc.subjectprimary cilia
dc.subjectPRIMARY CILIUM
dc.subjectPATHWAY
dc.subjectREGENERATION
dc.subjectGROWTH
dc.subjectGLI2
dc.subjectVIVO
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells
dc.typeartículo
dc.volumen90
sipa.codpersvinculados1008613
sipa.codpersvinculados1006488
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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