Follow-up of gallbladder polyps in a high-risk population of gallbladder cancer: a cohort study and multivariate survival competing risk analysis

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dc.catalogadorpva
dc.contributor.authorCandia Balboa, Roberto Andrés
dc.contributor.authorViñuela Morales, Macarena Rocío
dc.contributor.authorChahuán Abde, Javier Nicolás
dc.contributor.authorDíaz Piga, Luis Antonio
dc.contributor.authorGándara, Vicente
dc.contributor.authorErrázuriz Gastellu, Pedro
dc.contributor.authorBustamante Herrera, Luis Felipe Alberto
dc.contributor.authorVillalón Friedrich, Alejandro Andrés
dc.contributor.authorHuete Garín, Alvaro
dc.contributor.authorCrovari Eulufi, Fernando
dc.contributor.authorBriceño Valenzuela, Eduardo Andrés
dc.date.accessioned2024-11-19T19:18:43Z
dc.date.available2024-11-19T19:18:43Z
dc.date.issued2021
dc.description.abstractThe risk of neoplasia in gallbladder polyps seems to be low, but the evidence from populations at high-risk of gallbladder cancer is limited. We aimed to estimate the risk and to identify the factors associated with neoplastic polyps in a high-risk Hispanic population. Methods: A retrospective cohort was recruited between January 2010 and December 2019 at a Chilean university center. Multivariate survival analyses were conducted. Fine–Gray models were fitted to account for competing risks. Covariate adjustment was conducted using propensity scores. The main outcome was the development of gallbladder adenomas or adenocarcinoma. Results: Overall, 748 patients were included, 59.6% underwent cholecystectomy. The median follow-up of patients not subjected to cholecystectomy was 54.7 months (12–128.6 months). Seventeen patients (2.27%) developed the outcome. After adjustment by age, sex, intralesional blood flow, lithiasis and gallbladder wall thickening, only polyp size (≥10 mm, adjusted-HR: 15.01, 95%CI: 5.4–48.2) and number of polyps (≥3 polyps, adjusted-HR: 0.11, 95%CI: 0.01–0.55) were associated with neoplasia. Conclusion: In a Hispanic population at high-risk for gallbladder cancer, gallbladder polyps seem to have a low risk of neoplasia. Polyp size was the main risk factor, while having multiple polyps was associated with an underlying benign condition.
dc.format.extent7 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.hpb.2021.11.009
dc.identifier.eissn1477-2574
dc.identifier.issn1365-182X
dc.identifier.scopusidSCOPUS_ID:85120776473
dc.identifier.urihttps://doi.org/10.1016/j.hpb.2021.11.009
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88597
dc.information.autorucEscuela de Medicina; Candia Balboa, Roberto Andrés; 0000-0003-1856-7737; 16705
dc.information.autorucEscuela de Medicina; Viñuela Morales, Macarena Rocío; S/I; 1028006
dc.information.autorucEscuela de Medicina; Chahuán Abde, Javier Nicolás; S/I; 187210
dc.information.autorucEscuela de Medicina; Díaz Piga, Luis Antonio; S/I; 179253
dc.information.autorucEscuela de Medicina; Gándara, Vicente; S/I; 234421
dc.information.autorucEscuela de Medicina; Errázuriz Gastellu, Pedro; S/I; 1028016
dc.information.autorucEscuela de Medicina; Bustamante Herrera, Luis Felipe Alberto; S/I; 171171
dc.information.autorucEscuela de Medicina; Villalón Friedrich, Alejandro Andrés; S/I; 237951
dc.information.autorucEscuela de Medicina; Huete Garín, Alvaro; 0000-0002-8746-1111; 731
dc.information.autorucEscuela de Medicina; Crovari Eulufi, Fernando; 0000-0001-5288-0968; 7156
dc.information.autorucEscuela de Medicina; Briceño Valenzuela, Eduardo Andrés; S/I; 18751
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1025
dc.pagina.inicio1019
dc.publisherElsevier B.V.
dc.revistaHPB
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFollow-up of gallbladder polyps in a high-risk population of gallbladder cancer: a cohort study and multivariate survival competing risk analysis
dc.typeartículo
dc.volumen24
sipa.codpersvinculados16705
sipa.codpersvinculados1028006
sipa.codpersvinculados187210
sipa.codpersvinculados179253
sipa.codpersvinculados234421
sipa.codpersvinculados1028016
sipa.codpersvinculados171171
sipa.codpersvinculados237951
sipa.codpersvinculados731
sipa.codpersvinculados7156
sipa.codpersvinculados18751
sipa.trazabilidadSCOPUS;21-03-2022
sipa.trazabilidadORCID;2024-11-18
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