Amino terminal sequence of heavy and light chains from ratfish immunoglobulin

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dc.contributor.authorDe Ioannes I., Alfredo E.
dc.contributor.authorAguila, Héctor L.
dc.date.accessioned2019-12-28T02:45:30Z
dc.date.available2019-12-28T02:45:30Z
dc.date.issued1989
dc.description.abstractThe ratfish,Callorhinchus callorhinchus, a representative of the Holocephali, has a natural serum hemagglutinin (Mr 960 000), composed of heavy (Mr 71000), light (Mr 22 500), and J (Mr 16 000) chains. To approach the mechanisms that generate diversity at this level of evolution, the amino terminal sequence of the heavy and light chains was determined by automated microsequencing. The chains are unblocked and have modest internal sequence heterogeneity. The heavy chains show sequence similarity with the terminal region of the heavy chain from the horned shark,Heterodontus francisci, and other species. In contrast to the heavy chain, the ratfish light chains display low sequence similarity with their shark kappa counterparts. However, their similarity with the variable region of the chicken lambda light chains is about 75%.
dc.format.extent5 páginas
dc.fuente.origenSpringer
dc.identifier.doi10.1007/BF02421203
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27133
dc.identifier.urihttps://doi.org/10.1007/BF02421203
dc.issue.numeroNo. 3
dc.pagina.final180
dc.pagina.inicio175
dc.revistaImmunogeneticses_ES
dc.rightsacceso restringido
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.otherPez - Fisiologíaes_ES
dc.subject.otherPez - Morfologíaes_ES
dc.subject.otherPez - Patologíaes_ES
dc.titleAmino terminal sequence of heavy and light chains from ratfish immunoglobulines_ES
dc.typeartículo
dc.volumenVol. 30
sipa.codpersvinculados98907
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