Carbamylated form of human erythropoietin normalizes cardiorespiratory disorders triggered by intermittent hypoxia mimicking sleep apnea syndrome

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dc.contributor.authorAndrade, David C.
dc.contributor.authorToledo, Camilo
dc.contributor.authorDiaz, Hugo S.
dc.contributor.authorPereyra, Katherin, V
dc.contributor.authorSchwarz, Karla G.
dc.contributor.authorDiaz Jara, Esteban
dc.contributor.authorMelipillan, Claudia
dc.contributor.authorRios Gallardo, Angelica P.
dc.contributor.authorUribe Ojeda, Atenea
dc.contributor.authorAlcayaga, Julio
dc.contributor.authorQuintanilla, Rodrigo A.
dc.contributor.authorIturriaga, Rodrigo
dc.contributor.authorRichalet, Jean Paul
dc.contributor.authorVoituron, Nicolas
dc.contributor.authorDel Rio, Rodrigo
dc.date.accessioned2024-01-10T13:44:17Z
dc.date.available2024-01-10T13:44:17Z
dc.date.issued2021
dc.description.abstractBackground and objective: Chronic intermittent hypoxia (CIH), one of the main features of obstructive sleep apnea (OSA), enhances carotid body-mediated chemoreflex and induces hypertension and breathing disorders. The carbamylated form of erythropoietin (cEpo) may have beneficial effects as it retains its antioxidant/anti-inflammatory and neuroprotective profile without increasing red blood cells number. However, no studies have evaluated the potential therapeutic effect of cEpo on CIH-related cardiorespiratory disorders. We aimed to determine whether cEpo normalized the CIH-enhanced carotid body ventilatory chemoreflex, the hypertension and ventilatory disorders in rats. Methods: Male Sprague-Dawley rats (250 g) were exposed to CIH (5% O-2, 12/h, 8 h/day) for 28 days. cEPO (20 mu g/kg, i.p) was administrated from day 21 every other day for one more week. Cardiovascular and respiratory function were assessed in freely moving animals. Results: Twenty-one days of CIH increased carotid body-mediated chemoreflex responses as evidenced by a significant increase in the hypoxic ventilatory response (FiO2 10%) and triggered irregular eupneic breathing, active expiration, and produced hypertension. cEpo treatment significantly reduced the carotid body--chemoreflex responses, normalizes breathing patterns and the hypertension in CIH. In addition, cEpo treatment effectively normalized carotid body chemosensory responses evoked by acute hypoxic stimulation in CIH rats. Conclusion: Present results strongly support beneficial cardiorespiratory therapeutic effects of cEpo during CIH exposure.
dc.description.funderFONDECYT from National Fund for Scientific and Technological Development of Chile
dc.description.funderECOSCONICYT
dc.fechaingreso.objetodigital2024-05-22
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/HJH.0000000000002756
dc.identifier.eissn1473-5598
dc.identifier.issn0263-6352
dc.identifier.pubmedidMEDLINE:33560061
dc.identifier.urihttps://doi.org/10.1097/HJH.0000000000002756
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78884
dc.identifier.wosidWOS:000647705300012
dc.information.autorucFacultad de Ciencias Biológicas; Iturriaga Aguera, Rodrigo Manuel; S/I; 59784
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1133
dc.pagina.inicio1125
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJOURNAL OF HYPERTENSION
dc.rightsacceso restringido
dc.subjectcarotid body chemoreflex
dc.subjectchronic intermittent hypoxia
dc.subjecterythropoietin
dc.subjecthypertension
dc.subjectobstructive sleep apnea
dc.subjectBODY CHEMOSENSORY ACTIVITY
dc.subjectRAT CAROTID-BODY
dc.subjectINDUCED APOPTOSIS
dc.subjectPOTENTIATION
dc.subjectINFLAMMATION
dc.subjectCELLS
dc.subjectHYPERTENSION
dc.subjectVENTILATION
dc.subjectACTIVATION
dc.subjectEXPRESSION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCarbamylated form of human erythropoietin normalizes cardiorespiratory disorders triggered by intermittent hypoxia mimicking sleep apnea syndrome
dc.typeartículo
dc.volumen39
sipa.codpersvinculados59784
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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