Clinical characteristics, risk factors, and outcomes in Chilean triple negative breast cancer patients: a real-world study

Simple item page
dc.article.number197
dc.catalogadoraba
dc.contributor.authorAcevedo Claros, Francisco Nicolás
dc.contributor.authorWalbaum, Benjamin
dc.contributor.authorMedina, Lidia
dc.contributor.authorMerino Lara, Tomás Rodrigo
dc.contributor.authorCamus Appuhn, Mauricio Gonzalo
dc.contributor.authorPuschel Illanes, Klaus
dc.contributor.authorRamírez Parada, Karol Lilia
dc.contributor.authorManzor, Manuel
dc.contributor.authorVeglia, Paulina
dc.contributor.authorMartinez, Raul
dc.contributor.authorGuerra, Constanza
dc.contributor.authorNavarro, Marisel
dc.contributor.authorBauerle, Catherine
dc.contributor.authorDomínguez Covarrubias, Francisco José
dc.contributor.authorSánchez Rojel, César Giovanni
dc.date.accessioned2024-01-17T19:36:04Z
dc.date.available2024-01-17T19:36:04Z
dc.date.issued2023
dc.description.abstractBackground Latin American (LA) studies on triple-negative breast cancer (TNBC) and their characteristics are scarce. This forces physicians to make clinical decisions based on data obtained from studies that include non-Hispanic patients. Our study sought to obtain local epidemiological data, including risk factors and clinical outcomes from a Chilean BC registry. Methods This was a retrospective population-cohort study that included patients treated at a community hospital (mid-low income) or an academic private center (high income), in the 2010-2021 period. Univariate and multivariate analyses were performed to identify prognostic factors associated with survival. Results 647 out of 5,806 BC patients (11.1%) were TNBC. These patients were younger (p = 0.0001) and displayed lower rates of screening-detected cases (p = 0.0001) compared to non-TNBC counterparts. Among TNBC patients, lower income (i. e., receiving treatment at a community hospital) was associated with poorer overall survival (HR: 1.53; p = 0.0001) and poorer BC specific survival (HR: 1.29; p = 0.004). Other risk factors showed no significant differences between TNBC and non-TNBC. As expected, 5-year OS was significantly shorter on TNBC versus non-TNBC patients (p = 0.00001). In our multivariate analyses TNBC subtype (HR: 2.30), locally advanced stage (HR: 7.04 for stage III), lower income (HR: 1.64), or non-screening detected BC (HR: 1.32) were associated with poorer OS. Conclusion To the best of our knowledge, this is the largest LA cohort of TNBC patients. Interestingly, the proportion of TNBC among Chileans was smaller compared to similar studies within LA. As expected, TNBC patients had poorer survival and higher risk for early recurrence versus non-TNBC. Other relevant findings include a higher proportion of premenopausal patients among TNBC. Also, mid/low-income patients that received medical attention at a community hospital displayed lower survival versus private health center counterparts.
dc.fechaingreso.objetodigital2024-01-19
dc.format.extent11 páginas
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1007/s10549-022-06814-x
dc.identifier.eissn1573-7217
dc.identifier.issn0167-6806
dc.identifier.scopusidSCOPUS_ID:85142241009
dc.identifier.urihttps://doi.org/10.1007/s10549-022-06814-x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80562
dc.identifier.wosidWOS:000886426000002
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolás; 0000-0003-3482-7746; 119540
dc.information.autorucEscuela de Medicina; Merino Lara, Tomás Rodrigo; S/I; 119017
dc.information.autorucEscuela de Medicina; Camus Appuhn, Mauricio Gonzalo; 0000-0002-8409-5240; 100235
dc.information.autorucEscuela de Medicina; Puschel Illanes, Klaus; 0000-0002-1362-1311; 83957
dc.information.autorucDepartamento de Ciencias de la Salud; Ramírez Parada, Karol Lilia; 0000-0002-9143-321X; 1005837
dc.information.autorucEscuela de Medicina; Domínguez Covarrubias, Francisco José; S/I; 630
dc.information.autorucEscuela de Medicina; Sánchez Rojel, César Giovanni; 0000-0002-2920-108X; 135644
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final459
dc.pagina.inicio449
dc.revistaBreast Cancer Research and Treatment
dc.rightsacceso restringido
dc.subjectTriple negative
dc.subjectBreast neoplasm
dc.subjectLatin-American
dc.subjectRisk factors
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical characteristics, risk factors, and outcomes in Chilean triple negative breast cancer patients: a real-world study
dc.typeartículo
dc.volumen197
sipa.codpersvinculados119540
sipa.codpersvinculados119017
sipa.codpersvinculados100235
sipa.codpersvinculados83957
sipa.codpersvinculados1005837
sipa.codpersvinculados630
sipa.codpersvinculados135644
sipa.indexWOS
sipa.indexSCOPUS
sipa.trazabilidadORCID;2024-01-08
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
CLINIC~1.PDF
Size:
88.77 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas