Contribution of resident memory CD8+ T cells to protective immunity against respiratory syncytial virus and their impact on vaccine design

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dc.catalogadordfo
dc.contributor.authorRetamal Díaz, Angello
dc.contributor.authorCovián, Camila
dc.contributor.authorPacheco, Gaspar A.
dc.contributor.authorCastiglione Matamala, Angelo T.
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorGonzález, Pablo A.
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-01-29T15:21:48Z
dc.date.available2024-01-29T15:21:48Z
dc.date.issued2019
dc.description.abstractWorldwide, human respiratory syncytial virus (RSV) is the most common etiological agent for acute lower respiratory tract infections (ALRI). RSV-ALRI is the major cause of hospital admissions in young children, and it can cause in-hospital deaths in children younger than six months old. Therefore, RSV remains one of the pathogens deemed most important for the generation of a vaccine. On the other hand, the effectiveness of a vaccine depends on the development of immunological memory against the pathogenic agent of interest. This memory is achieved by long-lived memory T cells, based on the establishment of an effective immune response to viral infections when subsequent exposures to the pathogen take place. Memory T cells can be classified into three subsets according to their expression of lymphoid homing receptors: central memory cells (T-CM), effector memory cells (T-EM) and resident memory T cells (T-RM). The latter subset consists of cells that are permanently found in non-lymphoid tissues and are capable of recognizing antigens and mounting an effective immune response at those sites. T-RM cells activate both innate and adaptive immune responses, thus establishing a robust and rapid response characterized by the production of large amounts of effector molecules. T-RM cells can also recognize antigenically unrelated pathogens and trigger an innate-like alarm with the recruitment of other immune cells. It is noteworthy that this rapid and effective immune response induced by T-RM cells make these cells an interesting aim in the design of vaccination strategies in order to establish T-RM cell populations to prevent respiratory infectious diseases. Here, we discuss the biogenesis of T-RM cells, their contribution to the resolution of respiratory viral infections and the induction of T-RM cells, which should be considered for the rational design of new vaccines against RSV.
dc.description.funderVRAID (ex DIPUC)
dc.fuente.origenHistorial Académico
dc.identifier.citationRetamal Diaz Angello Ricardo, Bueno Ramirez Susan Marcela, Gonzalez Munoz Pablo Alberto, Kalergis Parra Alexis Mikes. Contribution of resident memory CD8+ T cells to protective immunity against respiratory syncytial virus and their impact on vaccine design. 2019;8(3):1-17.
dc.identifier.doi10.3390/pathogens8030147
dc.identifier.issn2076-0817
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81002
dc.identifier.wosidWOS:000488003600024
dc.information.autorucFacultad de Ciencias Biológicas; Retamal Diaz Angello Ricardo; 0000-0002-8840-1911; 225150
dc.information.autorucFacultad de Ciencias Biológicas; Pacheco Ruidiaz Gaspar Andres; S/I; 1047198
dc.information.autorucFacultad de Ciencias Biológicas; Castiglione Matamala Angelo Tomas; ; 1027831
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramirez Susan Marcela; 0000-0002-7551-8088; 113541
dc.information.autorucEscuela de Medicina; Kalergis Parra Alexis Mikes; 0000-0001-7622-5263; 90610
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final17
dc.pagina.inicio1
dc.revistaPathogens
dc.rightsacceso restringido
dc.subjectHuman respiratory syncytial virus
dc.subjectHuman orthopneumovirus
dc.subjectRespiratory infection
dc.subjectResident memory T cells
dc.subjectVaccine development
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleContribution of resident memory CD8+ T cells to protective immunity against respiratory syncytial virus and their impact on vaccine design
dc.typeartículo
dc.volumen8
sipa.codpersvinculados225150
sipa.codpersvinculados1047198
sipa.codpersvinculados1027831
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.trazabilidadHistorial Académico;09-07-2021
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