Microsatellite instability and loss of heterozygosity have distinct prognostic value for testicular germ cell tumor recurrence

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dc.contributor.authorVelasco, A
dc.contributor.authorRiquelme, E
dc.contributor.authorSchultz, M
dc.contributor.authorWistuba, II
dc.contributor.authorVillarroel, L
dc.contributor.authorKoh, MS
dc.contributor.authorLeach, FS
dc.date.accessioned2024-01-10T13:50:33Z
dc.date.available2024-01-10T13:50:33Z
dc.date.issued2004
dc.description.abstractGerm cell tumor (GCT) is the most common genitourinary malignancy of men between the ages of 18 and 35 years. Therapy is ultimately successful in over 90% of patients, however significant morbidity and mortality can be associated with adjuvant treatment and relapse. Molecular markers that predict treatment response and/or poor outcome would have immediate clinical benefit since adjuvant treatment could be selectively reserved for patients at higher risk for relapse and those patients most likely to respond to treatment. In order to identify potential prognostic molecular markers, we evaluated 118 GCT for microsatellite instability (MSI), loss of heterozygosity (LOH) and MSH2 immunostaining to identify tumors associated with relapse and/or poor outcome following initial surgical, medical and/or radiation therapy.
dc.description.abstractMSI in 3 or more markers and/or low MSH2 staining were associated with relapse while LOH in the absence of MSI and/or high MSH2 staining were not. Twenty-five percent of GCT exhibited genetic instability in 3 or more microsatellite markers (MSI+ tumors), 15% exhibited LOH in the absence of MSI (LOH only tumors) and 44% exhibited decreased or absent MSH2 immunostaining (low MSH2 staining tumors). Thirty-six patients (30%) relapsed and 27 of these patients (75%) had MSI+ and/or low MSH2 staining tumors. Only one patient (3%) with an LOH only tumor and no patients with high MSH2 staining and LOH only tumors relapsed. Therefore distinct GCT subpopulations identified by detection of MSI, LOH and MMR expression are associated with different clinical outcomes. MMR deficient testicular GCT with increased frequency of MSI had an increased association with tumor recurrence compared to GCT with an intact MMR system and LOH in the absence of MSI.
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4161/cbt.3.11.1218
dc.identifier.eissn1555-8576
dc.identifier.issn1538-4047
dc.identifier.pubmedidMEDLINE:15492498
dc.identifier.urihttps://doi.org/10.4161/cbt.3.11.1218
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79538
dc.identifier.wosidWOS:000228135800028
dc.information.autorucMedicina;Velasco A;S/I;58191
dc.issue.numero11
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final1158
dc.pagina.inicio1152
dc.publisherTAYLOR & FRANCIS INC
dc.revistaCANCER BIOLOGY & THERAPY
dc.rightsregistro bibliográfico
dc.subjectgenetic instability
dc.subjectgerm cell tumor
dc.subjectmismatch repair
dc.subjecttesticular cancer
dc.subjectCLINICAL STAGE-I
dc.subjectREPAIR GENE HMSH2
dc.subjectMISMATCH REPAIR
dc.subjectCANCER
dc.subjectSURVEILLANCE
dc.subjectEXPRESSION
dc.subjectTESTIS
dc.subjectNONSEMINOMA
dc.subjectMANAGEMENT
dc.subjectMUTATIONS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMicrosatellite instability and loss of heterozygosity have distinct prognostic value for testicular germ cell tumor recurrence
dc.typeartículo
dc.volumen3
sipa.codpersvinculados58191
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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