High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile

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dc.catalogadorgjm
dc.contributor.authorGuzman, Leda M.
dc.contributor.authorKoriyama, Chihaya
dc.contributor.authorAkiba, Suminori
dc.contributor.authorEizuru, Yoshito
dc.contributor.authorCastillo, Darwins
dc.contributor.authorCorvalán R., Alejandro
dc.contributor.authorAguayo González, Francisco
dc.date.accessioned2024-06-07T15:49:03Z
dc.date.available2024-06-07T15:49:03Z
dc.date.issued2007
dc.description.abstractThe inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer. The p16 gene is a tumour suppressor gene involved in the regulation of cell cycle progression that has been reported to be inactivated by promoter methylation in lung carcinomas at variable frequencies around the world in a smoking habit dependent manner. The purpose of this study was to investigate the methylation status of the promoter region of the p16 gene in 74 non-small cell lung carcinomas from Chile. The frequency of p16 gene inactivation by promoter methylation was determined as 79.7% (59/74). When we considered histological type, we observed that p16 promoter methylation was significantly higher in squamous cell carcinomas (30/33, 91%) compared with adenocarcinomas (21/30, 70%) (p=0.029). In addition, no association between p16 promoter methylation and gender, age or smoking habit was found (p=0.202, 0.202 and 0.147 respectively). Our results suggest that p16 promoter hypermethylation is a very frequent event in non-small cell lung carcinomas from Chile and could be smoking habit-independent.
dc.fechaingreso.objetodigital2024-06-07
dc.fuente.origenORCID
dc.identifier.doi10.4067/S0716-97602007000400011
dc.identifier.issn0716-9760
dc.identifier.pubmedidMEDLINE:18449464
dc.identifier.urihttps://doi.org/10.4067/S0716-97602007000400011
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86630
dc.identifier.wosidWOS:000254493600011
dc.information.autorucEscuela de Medicina; Corvalán R., Alejandro; 0000-0001-5492-3853; 63885
dc.information.autorucEscuela de Medicina; Aguayo González, Francisco; S/I; 1005475
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final372
dc.pagina.inicio365
dc.revistaBiological Research
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 ATTRIBUTION 4.0 INTERNATIONAL Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectLung carcinoma
dc.subjectMethylation
dc.subjectPromoter region
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHigh frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
dc.typeartículo
dc.volumen40
sipa.codpersvinculados63885
sipa.codpersvinculados1005475
sipa.trazabilidadORCID;2024-06-03
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