Risk factors for the development of lung cancer in a cohort of adult smokers

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dc.contributor.authorSaldias Penafiel, Fernando
dc.contributor.authorElola Aranguiz, Jose Manuel
dc.contributor.authorUribe Monasterio, Javier
dc.contributor.authorMorales Soto, Arturo
dc.contributor.authorDiaz Patino, Orlando
dc.date.accessioned2024-01-10T12:08:18Z
dc.date.available2024-01-10T12:08:18Z
dc.date.issued2016
dc.description.abstractBackground: Identifying risk factors for lung cancer in the population could improve the cost-effectiveness of early detection programs using thoracic computed tomography (CT). Aim: To examine the risk factors of lung cancer in a cohort of adult smokers. Patients and Methods: An annual clinical and respiratory functional assessment, chest computed tomography for three years and clinical follow up for five years was carried out in 270 patients aged 65 +/- 9 years, 55% males, active or former smokers of 10 or more pack-years. Results: Thirty seven percent of patients were active smokers, consuming 37 +/- 26 packs/year, 85% had comorbidities, especially chronic obstructive pulmonary disease (COPD) (66%), hypertension (48%), diabetes (22%) and dyslipidemia (42%). Thirteen percent of patients had family history of lung cancer. Twenty-one cases of lung cancer were detected in the five years follow up, especially squamous cell carcinoma and adenocarcinoma. In the univariate analysis, the main risk factors for lung cancer identified were an age older than 60 years, history of COPD, family history of lung cancer, active smoking, tobacco consumption more than 30 pack/year and lung hyperinflation. In multivariate analysis, the three independent risk factors for lung cancer were a family history of lung cancer, active smoking and the number of packs per year of tobacco consumption. Conclusions: The identification of risk groups probably will improve the performance of programs for early detection of lung cancer.
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:28394954
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76378
dc.identifier.wosidWOS:000390353000003
dc.information.autorucMedicina;Diaz O;S/I;78564
dc.information.autorucMedicina;Elola J;S/I;177204
dc.information.autorucMedicina;Morales A;S/I;15243
dc.information.autorucMedicina;Saldias F;S/I;67197
dc.information.autorucMedicina;Uribe J;S/I;205690
dc.issue.numero11
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1390
dc.pagina.inicio1382
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectEarly Detective of Cancer
dc.subjectEarly Diagnosis
dc.subjectLung Cancer
dc.subjectRisk Factors
dc.subjectTobacco Smoking
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE
dc.subjectLOW-DOSE CT
dc.subjectPREDICTION MODEL
dc.subjectFAMILY-HISTORY
dc.subjectTRIAL
dc.subjectSTANDARDIZATION
dc.subjectVALIDATION
dc.subjectSMOKING
dc.subjectPOPULATION
dc.subjectPROJECT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRisk factors for the development of lung cancer in a cohort of adult smokers
dc.typeartículo
dc.volumen144
sipa.codpersvinculados78564
sipa.codpersvinculados177204
sipa.codpersvinculados15243
sipa.codpersvinculados67197
sipa.codpersvinculados205690
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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