Heme Oxygenase-1 Expression in Dendritic Cells Contributes to Protective Immunity against Herpes Simplex Virus Skin Infection

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dc.catalogadorgrr
dc.contributor.authorTognarelli Torres, Eduardo Ignacio
dc.contributor.authorDuarte Peñaloza, Luisa Fernanda
dc.contributor.authorFarías León, Mónica Andrea
dc.contributor.authorCancino Prado, Felipe Andrés
dc.contributor.authorCorrales Bonilla, Nicolas
dc.contributor.authorIbañez Irribarra, Francisco Javier
dc.contributor.authorRiedel Soria, Claudia
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorKalergis Parra,Alexis Mikes
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.date.accessioned2024-01-24T20:01:59Z
dc.date.available2024-01-24T20:01:59Z
dc.date.issued2023
dc.description.abstractHerpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections are highly prevalent in the human population and produce mild to life-threatening diseases. These viruses interfere with the function and viability of dendritic cells (DCs), which are professional antigen-presenting cells that initiate and regulate the host's antiviral immune responses. Heme oxygenase-1 (HO-1) is an inducible host enzyme with reported antiviral activity against HSVs in epithelial cells and neurons. Here, we sought to assess whether HO-1 modulates the function and viability of DCs upon infection with HSV-1 or HSV-2. We found that the stimulation of HO-1 expression in HSV-inoculated DCs significantly recovered the viability of these cells and hampered viral egress. Furthermore, HSV-infected DCs stimulated to express HO-1 promoted the expression of anti-inflammatory molecules, such as PDL-1 and IL-10, and the activation of virus-specific CD4(+) T cells with regulatory (Treg), Th17 and Treg/Th17 phenotypes. Moreover, HSV-infected DCs stimulated to express HO-1 and then transferred into mice, promoted the activation of virus-specific T cells and improved the outcome of HSV-1 skin infection. These findings suggest that stimulation of HO-1 expression in DCs limits the deleterious effects of HSVs over these cells and induces a favorable virus-specific immune response in the skin against HSV-1.
dc.fechaingreso.objetodigital2024-01-24
dc.format.extent20 páginas
dc.fuente.origenORCID;2024-01-15
dc.identifier.doi10.3390/antiox12061170
dc.identifier.eissn2076-3921
dc.identifier.pubmedid37371900
dc.identifier.scopusidSCOPUS_ID:85163880524
dc.identifier.urihttps://doi.org/10.3390/antiox12061170
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80945
dc.identifier.wosidWOS:001016845100001
dc.information.autorucFacultad de Ciencias Biológicas; Tognarelli Torres Eduardo Ignacio; 0000-0003-0038-0704; 195523
dc.information.autorucFacultad de Ciencias Biológicas; Duarte Peñaloza, Luisa Fernanda; 0000-0003-1828-1800; 1031205
dc.information.autorucFacultad de Ciencias Biológicas; Farías León, Mónica Andrea; 0000-0003-0550-2002; 205467
dc.information.autorucFacultad de Ciencias Biológicas; Cancino Prado, Felipe Andrés; 0000-0002-8287-171X; 1027865
dc.information.autorucFacultad de Ciencias Biológicas; Corrales Bonilla, Nicolas; 0000-0001-8623-4518; 247402
dc.information.autorucFacultad de Ciencias Biológicas; Ibañez Irribarra, Francisco Javier; S/I; 237266
dc.information.autorucFacultad de Ciencias Biológicas; Riedel Soria, Claudia; 0000-0001-6168-8601; 88772
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra,Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherMDPI
dc.revistaAntioxidants
dc.rightsacceso abierto
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectHeme oxygenase-1
dc.subjectDendritic cells
dc.subjectAdaptive response
dc.subjectSkin infection
dc.subjectAntiviral drug
dc.subjectHerpes simplex virus
dc.subjectTh17
dc.subjectTreg
dc.subjectTreg/Th17
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHeme Oxygenase-1 Expression in Dendritic Cells Contributes to Protective Immunity against Herpes Simplex Virus Skin Infection
dc.typeartículo
dc.volumen12
sipa.codpersvinculados195523
sipa.codpersvinculados1031205
sipa.codpersvinculados205467
sipa.codpersvinculados1027865
sipa.codpersvinculados247402
sipa.codpersvinculados237266
sipa.codpersvinculados88772
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.codpersvinculados15616
sipa.trazabilidadWOS;2023-07-30
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