Adverse drug reactions (ADRs) in patients with HIV infection. A prospective study

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dc.contributor.authorGonzalez Martin, G
dc.contributor.authorYanez, CG
dc.contributor.authorGonzalez Contreras, L
dc.contributor.authorLabarca, J
dc.date.accessioned2024-01-10T13:10:55Z
dc.date.available2024-01-10T13:10:55Z
dc.date.issued1999
dc.description.abstractAim A prospective drug surveillance method was used to monitor 50 ambulatory patients with HIV infection, who were controlled in the Sexual Transmission Disease Service at Dr. Sotero del Rio Hospital (Santiago, Chile). The aim of this work was to characterize and study the frequency, characteristics, and associated factors of the ADRs in HIV-infected patients. Patients and methods: Patients were interrogated once or twice a month by a clinical pharmacist, who consigned data concerning the drug prescribed by the physician, drug-related signs and symptoms, and the laboratory's parameters as renal, hepatic, hematological function, and biochemical test. The ADR probability was assessed for an algorithm. Results: The frequency of adverse drug reactions found in the group of patients studied was 32.0%. The dermatological, hepatic, and hematological systems were the most affected by adverse drug reactions. Trimethroprim-sulfamethoxazole and zidovudine were the drugs mainly associated with ADRs. Patients with lymphocytes CD4+ count of 200 or less, presented a higher frequency of ADRs. 48.5% of ADRs were classified as probable. Severe reactions were found in 18.5% of the patients, and moderate in 70.4%. 50% of patients with ADRs needed the withdrawal of the implicated drug, and an 18.5% dose decreased. 63% gf the ADRs were dose-independent, Conclusion: There was a higher frequency of ADRs in those patients with multiple-drug therapy, but the frequency of ADR was not associated with age, gender, or hematological test.
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.issn0946-1965
dc.identifier.pubmedidMEDLINE:10027481
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77961
dc.identifier.wosidWOS:000078609300005
dc.information.autorucQuímica;González G;S/I;98524
dc.issue.numero1
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final40
dc.pagina.inicio34
dc.publisherDUSTRI-VERLAG DR KARL FEISTLE
dc.revistaINTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
dc.rightsregistro bibliográfico
dc.subjectHIV-positive patients
dc.subjectadverse drug reactions
dc.subjectcotrimoxazol
dc.subjectAZT
dc.subjectACQUIRED-IMMUNODEFICIENCY-SYNDROME
dc.subjectPNEUMOCYSTIS-CARINII PNEUMONIA
dc.subjectTRIMETHOPRIM-SULFAMETHOXAZOLE
dc.subjectVIRUS INFECTION
dc.subjectDISEASE
dc.subjectPHARMACOKINETICS
dc.subjectINDIVIDUALS
dc.subjectZIDOVUDINE
dc.subjectAIDS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAdverse drug reactions (ADRs) in patients with HIV infection. A prospective study
dc.typeartículo
dc.volumen37
sipa.codpersvinculados98524
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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