Synthesis and Anticancer Properties of 'azole' based Chemotherapeutics as Emerging Chemical Moieties: A Comprehensive Review

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dc.catalogadoryvc
dc.contributor.authorPrasher, P.
dc.contributor.authorSharma, M.
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorGupta, G.
dc.contributor.authorAjabali, Alaa A. A.
dc.contributor.authorMishra, V.
dc.contributor.authorTambuwala, M. M.
dc.contributor.authorKapoor, D. N.
dc.contributor.authorNegi, P.
dc.contributor.authorAndreoli Pinto, Terezinha de Jesús
dc.contributor.authorSingh, I.
dc.contributor.authorChellappan, D.
dc.contributor.authorDua, Kamal
dc.date.accessioned2023-08-29T14:22:30Z
dc.date.available2023-08-29T14:22:30Z
dc.date.issued2020
dc.description.abstractAzole frameworks serve as privileged scaffolds in the contemporary drug design paradigm owing to their unique physicochemical profile that promotes the development of highly selective, physiological benevolent chemotherapeutics. Several azole nuclei function as bioisostere in medicinal chemistry and prompt the development of tailored therapeutics for targeting the desired biological entities. Besides, the azole scaffold forms an integral part in the advanced drug designing methodologies, such as target template insitu drug synthesis, that assists in rapid identification of the hit molecules form a diverse pool of leads; and direct biomolecule-drug conjugation, along with bioorthogonal strategies that ensure localization, and superior target specificity of the directed therapeutic. Lastly, the structural diversity of azole framework and high yielding click synthetic methods provide a comprehensive Structure-Activity Relationship analysis for design optimization of the potential drug molecules by fine-tuning the placement of different substituents critical for the activity. This review provides a comprehensive analysis of the synthesis and anticancer potential of azole based chemotherapeutics.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2023-08-29
dc.fuente.origenHistorial Académico
dc.identifier.citationPrasher, P.; Sharma, M.; et Zacconi, Flavia C. M. (2020). Synthesis and anticancer properties of 'azole' based chemotherapeutics as emerging chemical moieties: a comprehensive review. Current Organic Chemistry;(185155):1-1.
dc.identifier.doi10.2174/1385272824999200820152501
dc.identifier.issn1385-2728
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74537
dc.identifier.wosidWOS:000634807100002
dc.information.autorucEscuela de Química ; Zacconi, Flavia C. M.; 0000-0002-3676-0453 ; 1011127
dc.issue.numero185155
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final668
dc.pagina.inicio654
dc.revistaCurrent Organic Chemistryes_ES
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynthesis and Anticancer Properties of 'azole' based Chemotherapeutics as Emerging Chemical Moieties: A Comprehensive Reviewes_ES
dc.typeartículo
dc.volumen25
sipa.codpersvinculados1011127
sipa.indexISI-2017-2018
sipa.indexScopus-2017
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadORCID;2023-08-20
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