Functional and biochemical characteristics of a putative quisqualate-type receptor in rat striatum: Effect of brain lesions

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dc.contributor.authorRudolph, Maria Isolde
dc.contributor.authorBustos O., Gonzalo
dc.date.accessioned2019-12-28T02:45:31Z
dc.date.available2019-12-28T02:45:31Z
dc.date.issued1986
dc.description.abstractExcitatory amino acids such asl-glutamate (Glu) and quisqualate (QUIS) markedly potentiated K+-evoked release of exogeneous [3H]dopamine (DA) from rat striatal slices. Intranstriatal kainic acid injections resulted in a total disappearance of the stimulatory effects of Glu on evoked-release of [3H]DA as well as in a parallel reduction in the maximal number (Bmax) of ad-aspartate-insensitivel-[3H]Glu binding site in striatal particulate fractions. Following cortical ablation, the potentiating effect of Glu on [3H]DA release in decorticated striatal slices lasted longer, compared to normal slices, and occured during the 2nd min following K+-depolarization. However, the extent (%) of Glu stimulation on [3H]DA release remained the same in decorticated and normal striatal slices. Cortical ablation produced also a significant decrease in the Bmax and in theK d' of thed-aspartateinsensitive binding site towardsl[3H]Glu. These results support the proposal that thed-aspartate-insensitive Glu binding site is somehow related to an amino acid receptor-mediated modulation of dopaminergic transmission in the rat corpus striatum.
dc.fuente.origenSpringer
dc.identifier.doi10.1007/BF00965772
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27139
dc.identifier.urihttp://link.springer.com/article/10.1007/BF00965772
dc.issue.numeroNo. 11
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaNeurochemical Researches_ES
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherLesiones cerebraleses_ES
dc.subject.otherCuerpo estriadoes_ES
dc.subject.otherReceptores de dopaminaes_ES
dc.subject.otherAminoacidoses_ES
dc.titleFunctional and biochemical characteristics of a putative quisqualate-type receptor in rat striatum: Effect of brain lesionses_ES
dc.typeartículo
dc.volumenVol. 11
sipa.codpersvinculados98496
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