Causes of death with a functioning graft among kidney allograft recipients

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dc.contributor.authorVega, Jorge
dc.contributor.authorVidela, Christian
dc.contributor.authorBorja, Hernan
dc.contributor.authorGoecke, Helmuth
dc.contributor.authorMartinez, Felipe
dc.contributor.authorBetancour, Pablo
dc.date.accessioned2024-01-10T12:04:34Z
dc.date.available2024-01-10T12:04:34Z
dc.date.issued2012
dc.description.abstractBackground: Death with a functioning graft (DWGF) is now one of the main causes of renal transplant (RTx) loss. Aim: To determine whether the causes of DWGF, characteristics of donors and recipients and complications of RTx have changed in the last two decades. Subjects and Methods: Cooperative study of a cohort of 418 kidney grafts performed between 1968 and 2010. Patients were divided into two groups according to whether their kidney transplants were performed between 1968 and 1992 (Group 1) or 1993 and 2010 (Group 2). Results: Sixty eight patients experienced DWGF. Infections were the leading cause of DWGF in both groups (38 and 41%, respectively), followed by cardiovascular diseases (24 and 23% respectively), gastrointestinal disorders (21 and 26% respectively) and cancer (17 and 10% respectively). There were no significant differences in causes of death between the two groups according to the time elapsed since the renal transplantation. In patients in Group 1, the interval between diagnosis of renal failure and dialysis (HD) and the interval between the start of HD and kidney transplantation were significantly lower than in Group 2. The former had also an increased number of acute rejections in the first five years of kidney transplantation (p < 0.001). In Group 2, patients more often received their kidneys from deceased donors, had previous kidney transplantation, higher rate of antibodies to a panel of lymphocytes and an increased incidence of cardiovascular disorders after five years of RTx. Conclusions: The proportion of graft loss due to DWGF has increased over the last 2 decades, but its causes have not changed significantly. Infections are the most common causes of DWGF followed by cardiovascular and digestive diseases. (Rev Med Chile 2012; 140: 295-304).
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:22689108
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75834
dc.identifier.wosidWOS:000302927100003
dc.information.autorucMedicina;Goecke H ;S/I;135642
dc.issue.numero3
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final304
dc.pagina.inicio295
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectImmunosuppressive agents
dc.subjectKidney transplantation
dc.subjectMorbidity
dc.subjectMortality
dc.subjectPrognosis
dc.subjectTreatment outcome
dc.subjectRENAL-TRANSPLANT RECIPIENTS
dc.subjectGLOMERULAR-FILTRATION-RATE
dc.subjectSERUM CREATININE
dc.subjectRISK-FACTORS
dc.subjectPATIENT SURVIVAL
dc.subjectSINGLE-CENTER
dc.subjectPREDICTION
dc.subjectINFECTION
dc.subjectMORTALITY
dc.subjectEQUATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCauses of death with a functioning graft among kidney allograft recipients
dc.typeartículo
dc.volumen140
sipa.codpersvinculados135642
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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