Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations

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dc.article.number22065
dc.catalogadoraba
dc.contributor.authorFarías, G.G.
dc.contributor.authorGodoy, J.A.
dc.contributor.authorCerpa, W.
dc.contributor.authorVarela-Nallar, L.
dc.contributor.authorInestrosa, N.C.
dc.date.accessioned2024-03-04T15:19:41Z
dc.date.available2024-03-04T15:19:41Z
dc.date.issued2010
dc.description.abstractWnt signaling regulates a wealth of aspects of nervous system development and function in embryonic stages and in adulthood. The expression of Wnt ligands and components of the Wnt signaling machinery in early stages of neural development has been related to its role in neurite patterning and in synaptogenesis. Moreover, its expression in the mature nervous system suggests a role for this pathway in synaptic maintenance and function. Therefore, it is of crucial relevance the understanding of the mechanisms by which Wnt signaling regulates these processes. Herein, we discuss how different Wnt ligands, acting through different Wnt signaling pathways, operate in pre- and postsynaptic regions to modulate synapse structure and function. We also elaborate on the idea that Wnt signaling pathways are a target for the treatment of neurodegenerative diseases that affect synaptic integrity, such as Alzheimer's disease. Developmental Dynamics 239:94–101, 2010. © 2009 Wiley-Liss, Inc.
dc.fechaingreso.objetodigital2024-02-26
dc.format.extent8 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1002/dvdy.22065
dc.identifier.eissn1097-0177
dc.identifier.issn1058-8388
dc.identifier.urihttps://doi.org/10.1002/dvdy.22065
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/82459
dc.identifier.wosidWOS:000273703900008
dc.information.autorucFacultad de Ciencias Biológicas; Cerpa Nebott, Waldo Francisco; 0000-0001-7344-0144; 16584
dc.issue.numero1 Special Issue
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final101
dc.pagina.inicio94
dc.revistaDevelopmental Dynamics
dc.rightsacceso restringido
dc.subjectNeurons
dc.subjectCanonical Wnt signaling
dc.subjectNoncanonical Wnt signaling
dc.subjectSynapse
dc.subjectAβ
dc.subjectSynaptotoxicity
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleWnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations
dc.typeartículo
dc.volumen239
sipa.codpersvinculados16584
sipa.trazabilidadORCID;2024-01-15
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