High prevalence of undiagnosed primary hyperaldosteronism among patients with essential hypertension

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dc.article.number106217
dc.contributor.authorMosso, L
dc.contributor.authorFardella, C
dc.contributor.authorMontero, J
dc.contributor.authorRojas, P
dc.contributor.authorSanchez, O
dc.contributor.authorRojas, V
dc.contributor.authorRojas, A
dc.contributor.authorHuete, A
dc.contributor.authorSoto, J
dc.contributor.authorForadori, A
dc.contributor.otherNCD Risk Factor Collaboration (NCD-RisC)
dc.date.accessioned2024-08-15T08:00:25Z
dc.date.available2024-08-15T08:00:25Z
dc.date.issued1999
dc.description.abstractBackground: Classically, primary hyperaldosteronism was diagnosed in no more than 1% of patients with hypertension, when hypokalemia was used as the screening test. However, numerous patients with primary hyperaldosteronism do not have hypokalemia nod the disease remains undiagnosed. Aim: To assess the prevalence of normokalemic primary hyperaldosteronism among patients classified as having essential hypertension. Patients and methods: One hundred hypertensive patients with a blood pressure over 145/95 were studied. Plasma aldosterone and plasma renin activity were measured in all. A primary hyperaldosteronism was diagnosed when high aldosterone levels (over 16 ng/dl) and low plasma renin activity (below 0.5 ng/ml/h) coexisted in two blood tests of the aldosterone/plasma renin activity ratio was over 50. A probable primary hyperaldosteronism was diagnosed whet? the ratio was between 25 and 50 and these patients were subjected to a Fludrocortisone test to confirm the diagnosis. A dexametasone suppression test was done to discard glucocorticoid remediable aldosteronism. An adrenal TAC scan was done to all patients with primary hyperaldosteronism. Results: A diagnosis of primary hyperaldosteronism was reached in ten patients. Seven had elevated aldosterone and low plasma renin activity. In three the diagnosis was confirmed with the fludrocortisone test. All ten patients had normal serum potassium levels. Dexametasone suppression test was positive in three patients that normalized their blood pressure levels. Adrenal TAC scans showed an adenoma in one patient and hyperplasia in another. Conclusions: Primary hyperaldosteronism is more frequent than previously thought, it is overlooked when hypokalemia is used as the screening test and it can only be diagnosed measuring plasma aldosterone and renin activity.
dc.description.funderANID through FONDECYT
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1161/01.HYP.34.4.779
dc.identifier.eissn1524-4563
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:10668287
dc.identifier.scopusidSCOPUS_ID:0346985951
dc.identifier.urihttps://doi.org/10.1161/01.HYP.34.4.779
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87471
dc.identifier.wosidWOS:000082403600006
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero7
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final806
dc.pagina.inicio800
dc.relation.ispartof92nd Meeting and Expo of the Endocrine Society (ENDO 2010), JUN 19-22, 2010, San Diego, CA
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectaldosterone
dc.subjecthyperladosteronison
dc.subjecthypertension
dc.subjecthypokalemia, renin
dc.subjectPLASMA-RENIN-ACTIVITY
dc.subjectPRIMARY ALDOSTERONISM
dc.subjectACTIVITY RATIO
dc.subjectDIAGNOSIS
dc.subjectVOLUNTEERS
dc.subjectP450C11AS
dc.subjectRELEASE
dc.subject.ddc550
dc.subject.deweyCiencias de la tierraes_ES
dc.titleHigh prevalence of undiagnosed primary hyperaldosteronism among patients with essential hypertension
dc.typeartículo
dc.volumen127
sipa.codpersvinculados88201
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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