Reduced microbial diversity of the nasopharyngeal microbiome in household contacts with latent tuberculosis infection

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dc.catalogadorvzp
dc.contributor.authorRuiz-Tagle Seguel, Cinthya Grace
dc.contributor.authorUgalde, Juan A.
dc.contributor.authorNaves Pichuante, Rodrigo Antonio
dc.contributor.authorAraos, Rafael
dc.contributor.authorGarcia Canete, Patricia Del Carmen
dc.contributor.authorBalcells Marty, Maria Elvira
dc.date.accessioned2023-11-10T16:15:08Z
dc.date.available2023-11-10T16:15:08Z
dc.date.issued2023
dc.description.abstractThe upper respiratory tract is an obliged pathway for respiratory pathogens and a healthy microbiota may support the host's mucosal immunity preventing infection. We analyzed the nasopharyngeal microbiome in tuberculosis household contacts (HHCs) and its association with latent tuberculosis infection (TBI). A prospective cohort of HHCs was established and latent TBI status was assessed by serial interferon-& gamma; release assay (IGRA). Nasopharyngeal swabs collected at baseline were processed for 16S rRNA gene sequencing. The 82 participants included in the analysis were classified as: (a) non-TBI [IGRA negative at baseline and follow-up, no active TB (n = 31)], (b) pre-TBI [IGRA negative at baseline but converted to IGRA positive or developed active TB at follow-up (n = 16)], and (c) TBI [IGRA positive at enrollment (n = 35)]. Predominant phyla were Actinobacteriota, Proteobacteria, Firmicutes and Bacteroidota. TBI group had a lower alpha diversity compared to non-TBI (p(adj) = 0.04) and pre-TBI (p(adj) = 0.04). Only TBI and non-TBI had beta diversity differences (p(adj) = 0.035). Core microbiomes' had unique genera, and genus showed differential abundance among groups. HHCs with established latent TBI showed reduced nasopharyngeal microbial diversity with distinctive taxonomical composition. Whether a pre-existing microbiome feature favors, are a consequence, or protects against Mycobacterium tuberculosis needs further investigation.
dc.description.funderANID/CONICYT FONDECYT
dc.fechaingreso.objetodigital2023-11-07
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-023-34052-8
dc.identifier.eissn20452322
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-023-34052-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75278
dc.identifier.wosidWOS:001022552200001
dc.information.autorucEscuela de Medicina; Ruiz-tagle Seguel Cinthya Grace; 0000-0002-4712-3302; 1098594
dc.information.autorucEscuela de Medicina; Naves Pichuante Rodrigo Antonio; 0000-0002-1203-3593; 200771
dc.information.autorucEscuela de Medicina; Garcia Canete Patricia Del Carmen; 0000-0002-5983-2392; 73909
dc.information.autorucEscuela de Medicina; Balcells Marty Maria Elvira; 0000-0002-7223-9665; 7462
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.publisherNATURE PORTFOLIO
dc.revistaScientific Reports
dc.rightsacceso restringido
dc.subjectHumans
dc.subjectInterferon-gamma Release Tests
dc.subjectLatent Tuberculosis
dc.subjectMicrobiota
dc.subjectMycobacterium tuberculosis
dc.subjectProspective Studies
dc.subjectRNA, Ribosomal, 16S
dc.subjectTuberculosis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleReduced microbial diversity of the nasopharyngeal microbiome in household contacts with latent tuberculosis infection
dc.typeartículo
dc.volumen13
sipa.codpersvinculados1098594
sipa.codpersvinculados200771
sipa.codpersvinculados73909
sipa.codpersvinculados7462
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