Frontoparietal connectivity correlates with working memory performance in multiple sclerosis

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dc.article.number9310
dc.catalogadoraba
dc.contributor.authorFigueroa Vargas, Alejandra
dc.contributor.authorCarcamo, Claudia
dc.contributor.authorHenriquez Ch, Rodrigo
dc.contributor.authorZamorano, Francisco
dc.contributor.authorCiampi Diaz, Ethel Leslie
dc.contributor.authorUribe San Martín, Reinaldo
dc.contributor.authorVásquez, Macarena
dc.contributor.authorAboitiz, Francisco
dc.contributor.authorBilleke, Pablo
dc.date.accessioned2024-01-17T19:36:05Z
dc.date.available2024-01-17T19:36:05Z
dc.date.issued2020
dc.description.abstractWorking Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.
dc.description.funderChilean National Scientific and Technological Research Commission (CONICYT)
dc.description.funderCentre for Cognitive Neuroscience of the Pontificia Universidad Catolica de Chile
dc.description.funderCentro de Investigacion en Complejidad Social (CICS) of the Universidad del Desarrollo de Chile
dc.fechaingreso.objetodigital2024-01-19
dc.format.extent13 páginas
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1038/s41598-020-66279-0
dc.identifier.eissn2045-2322
dc.identifier.pubmedidMEDLINE:32518271
dc.identifier.urihttps://doi.org/10.1038/s41598-020-66279-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80571
dc.identifier.wosidWOS:000543956000048
dc.information.autorucEscuela de Medicina; Ciampi Diaz, Ethel Leslie; 0000-0002-7330-5433; 132794
dc.information.autorucEscuela de Medicina; Uribe San Martín, Reinaldo; 0000-0002-3422-7962; 127201
dc.information.autorucEscuela de Medicina; Aboitiz, Francisco; 0000-0003-3253-8123; 100165
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final13
dc.pagina.inicio1
dc.revistaScientific Reports
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 DEEDAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPRINCIPAL-COMPONENTS-ANALYSIS
dc.subjectANTERIOR CINGULATE CORTEX
dc.subjectERP GENERATOR PATTERNS
dc.subjectLAPLACIAN WAVE-FORMS
dc.subjectCOGNITIVE IMPAIRMENT
dc.subjectFUNCTIONAL CONNECTIVITY
dc.subjectTHETA OSCILLATIONS
dc.subjectGENERIC METHOD
dc.subjectNETWORKS
dc.subjectATTENTION
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFrontoparietal connectivity correlates with working memory performance in multiple sclerosis
dc.typeartículo
dc.volumen10
sipa.codpersvinculados100165
sipa.codpersvinculados181481
sipa.codpersvinculados562
sipa.codpersvinculados132794
sipa.codpersvinculados127201
sipa.codpersvinculados124689
sipa.codpersvinculados1013048
sipa.codpersvinculados1096783
sipa.indexWoS
sipa.indexPubmed
sipa.trazabilidadORCID;2024-01-08
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