Collapsibility of Lung Volume by Paired Inspiratiory and Expiratory CT Scans: Correlations with Lung Function and Mean Lung Density

Simple item page
dc.contributor.authorYamashiro, Tsuneo
dc.contributor.authorMatsuoka, Shin
dc.contributor.authorBartholmai, Brian J.
dc.contributor.authorEstepar, Raul San Jose
dc.contributor.authorRoss, James C.
dc.contributor.authorDiaz, Alejandro
dc.contributor.authorMurayama, Sadayuki
dc.contributor.authorSilverman, Edwin K.
dc.contributor.authorHatabu, Hiroto
dc.contributor.authorWashko, George R.
dc.date.accessioned2024-01-10T12:04:40Z
dc.date.available2024-01-10T12:04:40Z
dc.date.issued2010
dc.description.abstractRationale and Objectives: To evaluate the relationship between measurements of lung volume (LV) on inspiratory/expiratory computed tomography (CT) scans, pulmonary function tests (PFT), and CT measurements of emphysema in individuals with chronic obstructive pulmonary disease.
dc.description.abstractMaterials and Methods: Forty-six smokers (20 females and 26 males; age range 46-81 years), enrolled in the Lung Tissue Research Consortium, underwent PFT and chest CT at full inspiration and expiration. Inspiratory and expiratory LV values were automatically measured by open-source software, and the expiratory/inspiratory (E/I) ratio of LV was calculated. Mean lung density (MILD) and low attenuation area percent (<-950 HU) were also measured. Correlations of LV measurements with lung function and other CT indices were evaluated by the Spearman rank correlation test.
dc.description.abstractResults: LV E/I ratio significantly correlated with the following: the percentage of predicted value of forced expiratory volume in the first second (FEV1), the ratio of FEV1 to forced vital capacity (FVC), and the ratio of residual volume (RV) to total lung capacity (TLC) (FEV1 %P, R = -0.56, P < .0001; FEV1/FVC, r = -0.59, P <.0001; RV/TLC, r = 0.57, P <.0001, respectively). A higher correlation coefficient was observed between expiratory LV and expiratory MILD (r = -0.73, P <.0001) than between inspiratory LV and inspiratory MILD (r = -0.46, P < .01). LV E/I ratio showed a very strong correlation to MILD E/I ratio (r = 0.95, P <.0001).
dc.description.abstractConclusions: LV E/I ratio can be considered to be equivalent to MLD E/I ratio and to reflect airflow limitation and air-trapping. Higher collapsibility of lung volume, observed by inspiratory/expiratory CT, indicates less severe conditions in chronic obstructive pulmonary disease.
dc.description.funderGlaxoSmithKline
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.fechaingreso.objetodigital2024-03-18
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.acra.2009.11.004
dc.identifier.eissn1878-4046
dc.identifier.issn1076-6332
dc.identifier.pubmedidMEDLINE:20060751
dc.identifier.urihttps://doi.org/10.1016/j.acra.2009.11.004
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75856
dc.identifier.wosidWOS:000275963400013
dc.information.autorucMedicina;Díaz A;S/I;104496
dc.issue.numero4
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final495
dc.pagina.inicio489
dc.publisherELSEVIER SCIENCE INC
dc.revistaACADEMIC RADIOLOGY
dc.rightsacceso restringido
dc.subjectLung volume
dc.subjectchronic obstructive pulmonary disease
dc.subjectcomputed tomography
dc.subjectpulmonary emphysema
dc.subjectairflow obstruction
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE
dc.subjectQUANTITATIVE ASSESSMENT
dc.subjectCOMPUTED-TOMOGRAPHY
dc.subjectHELICAL CT
dc.subjectAIRWAY-OBSTRUCTION
dc.subjectREDUCTION SURGERY
dc.subjectEMPHYSEMA
dc.subjectATTENUATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCollapsibility of Lung Volume by Paired Inspiratiory and Expiratory CT Scans: Correlations with Lung Function and Mean Lung Density
dc.typeartículo
dc.volumen17
sipa.codpersvinculados104496
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-03-18. Collapsibility of Lung Volume by Paired Inspiratory and Expiratory CT Scans.pdf
Size:
206.08 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas