Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and beta cell dysfunction

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dc.contributor.authorBaudrand, Rene
dc.contributor.authorCampino, Carmen
dc.contributor.authorCarvajal, Cristian A.
dc.contributor.authorOlivieri, Oliviero
dc.contributor.authorGuidi, Giancesare
dc.contributor.authorFaccini, Giovanni
dc.contributor.authorSateler, Javiera
dc.contributor.authorCornejo, Javiera
dc.contributor.authorSan Martin, Betty
dc.contributor.authorDominguez, Jose M.
dc.contributor.authorCerda, Jaime
dc.contributor.authorMosso, Lorena M.
dc.contributor.authorOwen, Gareth I.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorFardella, Carlos E.
dc.date.accessioned2024-01-10T13:13:47Z
dc.date.available2024-01-10T13:13:47Z
dc.date.issued2011
dc.description.abstractMetabolic syndrome (MetS) may have increased cortisol (F) production caused by 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1) in liver and adipose tissue and/or by HPA axis dysregulation. F is then mainly metabolized by liver reductases into inactive tetrahydrometabolites (THMs). We measured THM levels in patients with or without MetS and evaluate the correlation between THMs and anthropometric and biochemical parameters. We recruited 221 subjects, of whom 130 had MetS by ATP III. We evaluated F, cortisone (E), adipokines, glucose, insulin and lipid profiles as well as urinary (24 h) F. E and THM levels. beta Cell function was estimated by the HOMA Calculator. We observed that patients with MetS showed higher levels of THMs, HOMA-IR and leptin and lower levels of adiponectin and HOMA-beta but no differences in F and E in plasma or urine. THM was associated with weight (r = +0.44, p < 0,001), waist circumference (r = +0.38, p < 0.01). glycemia (r = +0.37, p < 0.01), and triglycerides (r = +0.18, p = 0.06) and negatively correlated with adiponectin (r = -0.36, p < 0.001), HOMA-beta (r = -0.21, p < 0.001) and HDL (r = -0.29, p < 0.01). In a logistic regression model, THM levels were associated with hypertension, hyperglycemia and dyslipidemia. We conclude that MetS is associated with increased urinary THMs but not with F and E levels in plasma or urine. Increased levels of THM, reflecting the daily cortisol production subsequently metabolized, are correlated with hypoadiponectinemia, hypertension, dyslipidemia, insulin resistance and beta cell dysfunction. A subtle increased in glucocorticoid production may further account for the phenotypic and biochemical similarities observed in central obesity and Cushing's syndrome. (C) 2011 Elsevier Inc. All rights reserved.
dc.description.funderFONDEF
dc.description.funderFondecyt
dc.description.funderMillennium Nucleus in Immunology and Immunotherapy
dc.fechaingreso.objetodigital11-04-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.steroids.2011.09.010
dc.identifier.eissn1878-5867
dc.identifier.issn0039-128X
dc.identifier.pubmedidMEDLINE:21996535
dc.identifier.urihttps://doi.org/10.1016/j.steroids.2011.09.010
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78340
dc.identifier.wosidWOS:000298273300009
dc.information.autorucMedicina;Baudrand R ;S/I;1024
dc.information.autorucMedicina;Campino C;S/I;99519
dc.information.autorucMedicina;Carvajal C;S/I;8586
dc.information.autorucMedicina;Cerda J ;S/I;3935
dc.information.autorucMedicina;Dominguez J;S/I;9629
dc.information.autorucMedicina;Fardella C;S/I;66235
dc.information.autorucCiencias Biológicas;Kalergis A;S/I;90610
dc.information.autorucMedicina;Mosso L;S/I;88201
dc.information.autorucCiencias Biológicas;Owen G;S/I;1000459
dc.information.autorucMedicina;Sateler J ;S/I;16523
dc.issue.numero14
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1581
dc.pagina.inicio1575
dc.publisherELSEVIER SCIENCE INC
dc.revistaSTEROIDS
dc.rightsacceso restringido
dc.subjectGlucocorticoid metabolites
dc.subjectMetabolic syndrome
dc.subject11 beta-Hydroxysteroid dehydrogenase
dc.subjectAdiponectin
dc.subjectInsulin resistance
dc.subject11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1
dc.subjectSPLANCHNIC CORTISOL PRODUCTION
dc.subjectPITUITARY-ADRENAL AXIS
dc.subjectADIPOSE-TISSUE
dc.subjectADIPONECTIN CONCENTRATIONS
dc.subject5-ALPHA-REDUCTASE ACTIVITY
dc.subjectSERUM ADIPONECTIN
dc.subjectVISCERAL OBESITY
dc.subjectWEIGHT-LOSS
dc.subjectSENSITIVITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIncreased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and beta cell dysfunction
dc.typeartículo
dc.volumen76
sipa.codpersvinculados1024
sipa.codpersvinculados99519
sipa.codpersvinculados8586
sipa.codpersvinculados3935
sipa.codpersvinculados9629
sipa.codpersvinculados66235
sipa.codpersvinculados90610
sipa.codpersvinculados88201
sipa.codpersvinculados1000459
sipa.codpersvinculados16523
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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