Aldosterone, Plasma Renin Activity, and Aldosterone/Renin Ratio in a Normotensive Healthy Pediatric Population

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dc.contributor.authorMartinez Aguayo, Alejandro
dc.contributor.authorAglony, Marlene
dc.contributor.authorCampino, Carmen
dc.contributor.authorGarcia, Hernan
dc.contributor.authorBancalari, Rodrigo
dc.contributor.authorBolte, Lillian
dc.contributor.authorAvalos, Carolina
dc.contributor.authorLoureiro, Carolina
dc.contributor.authorCarvajal, Cristian A.
dc.contributor.authorAvila, Alejandra
dc.contributor.authorPerez, Viviana
dc.contributor.authorInostroza, Andrea
dc.contributor.authorFardella, Carlos E.
dc.date.accessioned2024-01-10T12:04:09Z
dc.date.available2024-01-10T12:04:09Z
dc.date.issued2010
dc.description.abstractPrimary aldosteronism is an important cause of secondary hypertension and is suspected in adults with an aldosterone/renin ratio >= 25. The normal aldosterone/renin ratio is unknown in children. The aim was to establish serum aldosterone, plasma renin activity, and aldosterone/renin ratio values in a healthy pediatric population. A cross-sectional study was performed in 211 healthy normotensive children (4 to 16 years old). Two subgroups of normotensive children were obtained: with hypertensive parents (NH) (n=113) and normotensive parents (n=98). Blood samples for measuring serum aldosterone, plasma renin activity, aldosterone/renin ratio, and DNA were collected. In subjects with aldosterone/renin ratio >= 25, the chimeric CYP11B1/CYP11B2 gene was investigated by long-extension PCR. Results are expressed as median [Q(1)-Q(3)]. NH and normotensive parents groups were similar in serum aldosterone (6.5 [3.6 to 9.0] ng/dL versus 6.5 [2.9 to 9.7] ng/dL; P=0.968) and plasma renin activity (2.3 [1.6 to 3.1] versus 2.4 [1.7 to 3.7] ng/mL per hour; P=0.129). The aldosterone/renin ratio was higher in the NH group, but this difference did not reach statistical significance (2.8 [1.9 to 4.1] versus 2.5 [1.4 to 4.0], P=0.104). In one subject of the NH group, the chimeric CYP11B1/CYP11B2 gene was detected. We demonstrated that normal aldosterone/renin ratio values in a healthy pediatric population without NH were lower than those reported for an adult normotensive population. (Hypertension. 2010;56:391-396.)
dc.description.funderFONDECYT
dc.description.funderBecas-Chile
dc.description.funderPontificia Universidad Catolica de Chile
dc.fechaingreso.objetodigital2024-05-20
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1161/HYPERTENSIONAHA.110.155135
dc.identifier.eissn1524-4563
dc.identifier.issn0194-911X
dc.identifier.pubmedidMEDLINE:20696993
dc.identifier.urihttps://doi.org/10.1161/HYPERTENSIONAHA.110.155135
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75704
dc.identifier.wosidWOS:000281132900015
dc.information.autorucMedicina;Aglony M;S/I;1273
dc.information.autorucMedicina;Bolte L;S/I;18472
dc.information.autorucMedicina;Campino C;S/I;99519
dc.information.autorucMedicina;Carvajal CA;S/I;8586
dc.information.autorucMedicina;Fardella C;S/I;66235
dc.information.autorucMedicina;García H;S/I;1006495
dc.information.autorucMedicina;Inostroza A;S/I;114125
dc.information.autorucMedicina;Loureiro C;S/I;126948
dc.information.autorucMedicina;Martínez-Aguayo A;S/I;1003862
dc.information.autorucMedicina;Pérez V;S/I;80854
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaHYPERTENSION
dc.rightsacceso restringido
dc.subjectprimary aldosteronism
dc.subjectplasma renin activity
dc.subjectarterial hypertension
dc.subjectaldosterone/plasma renin activity ratio
dc.subjectPRIMARY HYPERALDOSTERONISM
dc.subjectBLOOD-PRESSURE
dc.subjectDIAGNOSIS
dc.subjectHYPERTENSION
dc.subjectPREVALENCE
dc.subjectCHILDREN
dc.subjectSOCIETY
dc.subjectTESTS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAldosterone, Plasma Renin Activity, and Aldosterone/Renin Ratio in a Normotensive Healthy Pediatric Population
dc.typeartículo
dc.volumen56
sipa.codpersvinculados1273
sipa.codpersvinculados18472
sipa.codpersvinculados99519
sipa.codpersvinculados8586
sipa.codpersvinculados66235
sipa.codpersvinculados1006495
sipa.codpersvinculados114125
sipa.codpersvinculados126948
sipa.codpersvinculados1003862
sipa.codpersvinculados80854
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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