Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both

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dc.contributor.authorValdivia Cabrera, Gonzalo
dc.contributor.authorOlloquequi, Jordi.
dc.contributor.authorJaime, Sergio.
dc.contributor.authorParra, Viviana.
dc.contributor.authorCornejo-Córdova, Elizabeth.
dc.contributor.authorAgustí, Àlvar.
dc.contributor.authorSilva O., Rafael.
dc.date.accessioned2019-10-17T14:02:30Z
dc.date.available2019-10-17T14:02:30Z
dc.date.issued2018
dc.date.updated2019-10-14T18:48:06Z
dc.description.abstractAbstract Background Exposure to noxious gases and particles contained in both tobacco smoking (TS) and biomass smoke (BS) are well recognized environmental risk factors for chronic obstructive pulmonary disease (COPD). COPD is characterized by an abnormal inflammatory response, both in the pulmonary and systemic compartments. The differential effects of TS, BS or their combined exposure have not been well characterized yet. This study sought to compare the lung function characteristics and systemic inflammatory response in COPD patients exposed to TS, BS or their combination. Methods Sociodemographic, clinical and lung functional parameters were compared across 49 COPD patients with a history of smoking and no BS exposure (TS COPD), 31 never-smoker COPD patients with BS exposure (BS COPD), 46 COPD patients with a combined exposure (TS + BS COPD) and 52 healthy controls (HC) who have never been exposed neither to TS or BS. Blood cell counts, C-reactive protein (CRP), fibrinogen and immunoglobulin E (IgE) levels were quantified in all four groups. Results TS + BS COPD patients exhibited significantly lower oxygen saturation than the rest of groups (p < 0.01). Spirometry and diffusing capacity were significantly higher in BS than in TS or TS + BS patients. CRP levels were significantly higher in TS COPD patients than in BS COPD group (p < 0.05), whereas fibrinogen was raised in COPD patients with a history of smoking (TS and TS + BS) when compared to control subjects (p < 0.01). Finally, COPD patients with BS exposure (BS and BS + TS groups) showed higher IgE levels than TS and HC (p < 0.05). Conclusions There are significant physiological and inflammatory differences between COPD patients with TS, BS and TS + BS exposures. The latter had worse blood oxygenation, whereas the raised levels of IgE in BS exposed patients suggests a differential Th2 systemic inflammatory pattern triggered by this pollutant.
dc.fuente.origenBiomed Central
dc.identifier.citationRespiratory Research. 2018 Jan 18;19(1):13
dc.identifier.doi10.1186/s12931-018-0718-y
dc.identifier.urihttps://doi.org/10.1186/s12931-018-0718-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26667
dc.issue.numeroNo. 13
dc.language.isoen
dc.pagina.final8
dc.pagina.inicio1
dc.revistaRespiratory Researches_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s).
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherTabaquismoes_ES
dc.subject.otherBiomasa forestales_ES
dc.subject.otherHumoes_ES
dc.subject.otherEnfermedad pulmonar obstructiva crónicaes_ES
dc.titleComparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or bothes_ES
dc.typeartículo
dc.volumenVol. 19
sipa.codpersvinculados57007
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