Primary aldosteronism and hypertensive disease

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dc.article.number106217
dc.contributor.authorMosso, L
dc.contributor.authorCarvajal, C
dc.contributor.authorGonzalez, A
dc.contributor.authorBarraza, A
dc.contributor.authorAvila, F
dc.contributor.authorMontero, J
dc.contributor.authorHuete, A
dc.contributor.authorGederlini, A
dc.contributor.authorFardella, CE
dc.contributor.otherNCD Risk Factor Collaboration (NCD-RisC)
dc.date.accessioned2024-08-15T08:00:26Z
dc.date.available2024-08-15T08:00:26Z
dc.date.issued2003
dc.description.abstractRecent studies in hypertensive populations that have used the serum aldosterone ( SA) to plasma renin activity (PRA) ratio as a screening test have demonstrated a high prevalence of primary aldosteronism (PA). This frequency is higher than that previously described when hypokalemia was used as a screening tool. However, other factors, such as the characteristics of hypertensive disease, could also influence the prevalence of PA. We studied 609 essential hypertensive patients, classified according to the Joint National Committee VI (JNC VI), in 3 different stages depending on the severity of their hypertensive disease. We measured SA and PRA and calculated the SA-PRA ratio for all patients. An SA-PRA ratio > 25 was detected in 63 of 609 patients, and the fludrocortisone test confirmed the PA diagnoses in 37 of 609 ( 6.1%) cases. PA prevalence according to hypertension stage was as follows: stage 1, 6 of 301 cases ( 1.99%); stage 2, 15 of 187 cases (8.02%); and stage 3, 16 of 121 cases (13.2%). PA patients were slightly younger than the other hypertensive patients ( 48.4 +/- 10.5 vs 53.6 +/- 10.2 years; P < 0.05). Serum potassium levels were normal in 36 of 37 PA patients; only 1 patient had minor hypokalemia. Computed tomography scans showed bilateral adrenal enlargement in 7 and an adrenal nodule in 2 cases. In summary, we found a high frequency of PA in essential hypertensives classified in stages 2 and 3 according to the JNC VI. The low frequency of computed tomography scan abnormalities and hypokalemia suggests that the diagnosis for most PA patients corresponds to attenuated forms of the disease.
dc.description.funderANID through FONDECYT
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1161/01.HYP.0000079505.25750.11
dc.identifier.eissn1524-4563
dc.identifier.issn0194-911X
dc.identifier.pubmedidMEDLINE:12796282
dc.identifier.scopusidSCOPUS_ID:0346985951
dc.identifier.urihttps://doi.org/10.1161/01.HYP.0000079505.25750.11
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87474
dc.identifier.wosidWOS:000184476200008
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero2
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final165
dc.pagina.inicio161
dc.relation.ispartof14th European Meeting on Hypertension, JUN 13-17, 2004, Paris, FRANCE
dc.revistaHYPERTENSION
dc.rightsregistro bibliográfico
dc.subjecthypertension, essential
dc.subjectaldosterone
dc.subjectrenin
dc.subjecthypokalemia
dc.subjectPLASMA-RENIN-ACTIVITY
dc.subjectACTIVITY RATIO
dc.subjectPREVALENCE
dc.subjectHYPERALDOSTERONISM
dc.subjectPOPULATIONS
dc.subjectCAUTIONS
dc.subjectADENOMA
dc.subject.ddc550
dc.subject.deweyCiencias de la tierraes_ES
dc.titlePrimary aldosteronism and hypertensive disease
dc.typeartículo
dc.volumen42
sipa.codpersvinculados88201
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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