Complicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico. Experiencia de un centro universitario

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dc.catalogadorpau
dc.contributor.authorMellado T., Patricio
dc.contributor.authorPeredo Orellana, Pilar Andrea
dc.contributor.authorValenzuela Mangini, Raúl Francisco
dc.contributor.authorArrese Jiménez, Marco
dc.contributor.authorPérez Ayuso, Rosa María
dc.contributor.authorDomínguez, Pilar
dc.contributor.authorGuerra Castro, Juan Francisco
dc.contributor.authorJarufe Cassis, Nicolás
dc.contributor.authorMartínez Castillo, Jorge
dc.date.accessioned2023-07-21T17:46:10Z
dc.date.available2023-07-21T17:46:10Z
dc.date.issued2008
dc.description.abstractBackground: Orthotopic liver transplantation (OLT) is the treatment of choice for multiple acute and chronic end-stage liver diseases as well as for selected cases of liver malignancy and liver-site metabolic disorders. Neurological impairment is a major source of morbidity and mortality following OLT. Aim: To describe the incidence and the type of neurological complications occurring in the post-operative period of OLT in patients transplanted in our hospital. Material and methods: Between March 1994 and August 2007, 76 adult patients underwent OLT. Data on incidence, time of onset, and outcome of central nervous system (CNS) complications have been obtained from our program data base and patient charts. Results: Twenty three patients (30.3%) had CNS complications following OLT. The leading complications were immunosuppressive drug-related neurological impairment in nine patients (39.1%), peripheral nerve damage in five patients (21.7%), central pontine myelinolysis in four patients (17.4%), cerebrovascular disease in three (13%) and CNS infection in three (13%). Most CNS events (90%) occurred in the first 2 weeks after OLT. Five patients with neurological complications died (22%). Conclusions: CNS complications occurred in almost one fifth of the population studied, and they had a poor outcome, as previously reported
dc.fechaingreso.objetodigital2024-03-22
dc.format.extent9 páginas
dc.fuente.origenORCID
dc.identifier.issn0034-9887
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-64249119203&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74250
dc.information.autorucEscuela de Medicina; Mellado T., Patricio; S/I; 3552
dc.information.autorucEscuela de Medicina; Peredo Orellana, Pilar Andrea; S/I; 14429
dc.information.autorucEscuela de Medicina; Valenzuela Mangini, Raúl Francisco; S/I; 72324
dc.information.autorucEscuela de Medicina; Arrese Jiménez, Marco; S/I; 76095
dc.information.autorucEscuela de Medicina; Pérez Ayuso, Rosa María; S/I; 100479
dc.information.autorucEscuela de Medicina; Guerra Castro, Juan Francisco; S/I; 159745
dc.information.autorucEscuela de Medicina; Jarufe Cassis, Nicolás; S/I; 104492
dc.information.autorucEscuela de Medicina; Martínez Castillo, Jorge; S/I; 65778
dc.issue.numero10
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final1263
dc.pagina.inicio1255
dc.revistaRevista médica de Chilees_ES
dc.rightsacceso abierto
dc.subjectCerebrovascular disease
dc.subjectLiver transplantation
dc.subjectMyelinolysis
dc.subjectCentral pontine
dc.titleComplicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico. Experiencia de un centro universitario
dc.title.alternativeNeurological complications following a liver transplantation. Experience from a Chilean centeres_ES
dc.typeartículo
dc.volumen136
sipa.codpersvinculados3552
sipa.codpersvinculados14429
sipa.codpersvinculados72324
sipa.codpersvinculados76095
sipa.codpersvinculados100479
sipa.codpersvinculados159745
sipa.codpersvinculados104492
sipa.codpersvinculados65778
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